Targeted chromosomal genomic alterations with modified single stranded oligonucleotides


Ontology type: sgo:Patent     


Patent Info

DATE

2007-08-21T00:00

AUTHORS

Eric B Kmiec , Howard B Gamper , Michael C Rice

ABSTRACT

Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2′-O-Me base analogs.

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2620", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Eric B Kmiec", 
        "type": "Person"
      }, 
      {
        "name": "Howard B Gamper", 
        "type": "Person"
      }, 
      {
        "name": "Michael C Rice", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/13684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001657769", 
          "https://doi.org/10.1038/13684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/13684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001657769", 
          "https://doi.org/10.1038/13684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-1119(99)00522-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004060752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.18.8298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011489267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.85.2.524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015722860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/27.4.1176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017866183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/4322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020567316", 
          "https://doi.org/10.1038/4322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/4322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020567316", 
          "https://doi.org/10.1038/4322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.285.5.545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026117182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.18.10349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033560585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001090050112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034893223", 
          "https://doi.org/10.1007/s001090050112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/28.21.4332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040730547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.17.11541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041786503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3300601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043341032", 
          "https://doi.org/10.1038/sj.gt.3300601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3300601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043341032", 
          "https://doi.org/10.1038/sj.gt.3300601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/29.20.4238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046383039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/86701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046501493", 
          "https://doi.org/10.1038/86701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/86701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046501493", 
          "https://doi.org/10.1038/86701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/16.3.791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046629961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/38410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048288589", 
          "https://doi.org/10.1038/38410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/38410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048288589", 
          "https://doi.org/10.1038/38410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.10.5363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052768417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052794585", 
          "https://doi.org/10.1038/sj.gt.3301414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052794585", 
          "https://doi.org/10.1038/sj.gt.3301414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi9921891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055218649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi9921891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055218649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/4.11.2081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059645238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.270.5235.404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062551465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.273.5280.1386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062554059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.290.5491.530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062571805"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-08-21T00:00", 
    "description": "

Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2′-O-Me base analogs.

", "id": "sg:patent.US-7258854-B2", "keywords": [ "genomic alteration", "oligonucleotides", "method", "composition", "invention", "terminal region", "phosphorothioate", "analog", "base analog" ], "name": "Targeted chromosomal genomic alterations with modified single stranded oligonucleotides", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.33489.35", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-7258854-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:29", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_03191.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-7258854-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-7258854-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-7258854-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-7258854-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

115 TRIPLES      15 PREDICATES      46 URIs      17 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-7258854-B2 schema:about anzsrc-for:2620
2 schema:author N5682ceea589b481a91afae62f62048b4
3 schema:citation sg:pub.10.1007/s001090050112
4 sg:pub.10.1038/13684
5 sg:pub.10.1038/38410
6 sg:pub.10.1038/4322
7 sg:pub.10.1038/86701
8 sg:pub.10.1038/sj.gt.3300601
9 sg:pub.10.1038/sj.gt.3301414
10 https://doi.org/10.1001/jama.285.5.545
11 https://doi.org/10.1016/s0378-1119(99)00522-3
12 https://doi.org/10.1021/bi9921891
13 https://doi.org/10.1073/pnas.85.2.524
14 https://doi.org/10.1073/pnas.92.18.8298
15 https://doi.org/10.1073/pnas.96.18.10349
16 https://doi.org/10.1073/pnas.97.10.5363
17 https://doi.org/10.1074/jbc.274.17.11541
18 https://doi.org/10.1093/hmg/4.11.2081
19 https://doi.org/10.1093/nar/16.3.791
20 https://doi.org/10.1093/nar/27.4.1176
21 https://doi.org/10.1093/nar/28.21.4332
22 https://doi.org/10.1093/nar/29.20.4238
23 https://doi.org/10.1126/science.270.5235.404
24 https://doi.org/10.1126/science.273.5280.1386
25 https://doi.org/10.1126/science.290.5491.530
26 schema:datePublished 2007-08-21T00:00
27 schema:description <p num="p-0001">Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2&#8242;-O-Me base analogs.</p>
28 schema:keywords analog
29 base analog
30 composition
31 genomic alteration
32 invention
33 method
34 oligonucleotides
35 phosphorothioate
36 terminal region
37 schema:name Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
38 schema:recipient https://www.grid.ac/institutes/grid.33489.35
39 schema:sameAs https://app.dimensions.ai/details/patent/US-7258854-B2
40 schema:sdDatePublished 2019-04-18T10:29
41 schema:sdLicense https://scigraph.springernature.com/explorer/license/
42 schema:sdPublisher Ne0a2931dad24445e9ff2911b0a17c84e
43 sgo:license sg:explorer/license/
44 sgo:sdDataset patents
45 rdf:type sgo:Patent
46 N4036ffd45dcf4d7b9b803e6d1c350bab schema:name Eric B Kmiec
47 rdf:type schema:Person
48 N5682ceea589b481a91afae62f62048b4 rdf:first N4036ffd45dcf4d7b9b803e6d1c350bab
49 rdf:rest Nb36d98121b864f0996da72a599f5baf6
50 N6203a11cc68f450695cba4c41700e2e4 schema:name Howard B Gamper
51 rdf:type schema:Person
52 N93ecd3ab30814d429eaad57b8e526fad rdf:first Naac711cc87dd4a56b9cc203b85003d62
53 rdf:rest rdf:nil
54 Naac711cc87dd4a56b9cc203b85003d62 schema:name Michael C Rice
55 rdf:type schema:Person
56 Nb36d98121b864f0996da72a599f5baf6 rdf:first N6203a11cc68f450695cba4c41700e2e4
57 rdf:rest N93ecd3ab30814d429eaad57b8e526fad
58 Ne0a2931dad24445e9ff2911b0a17c84e schema:name Springer Nature - SN SciGraph project
59 rdf:type schema:Organization
60 anzsrc-for:2620 schema:inDefinedTermSet anzsrc-for:
61 rdf:type schema:DefinedTerm
62 sg:pub.10.1007/s001090050112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034893223
63 https://doi.org/10.1007/s001090050112
64 rdf:type schema:CreativeWork
65 sg:pub.10.1038/13684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001657769
66 https://doi.org/10.1038/13684
67 rdf:type schema:CreativeWork
68 sg:pub.10.1038/38410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048288589
69 https://doi.org/10.1038/38410
70 rdf:type schema:CreativeWork
71 sg:pub.10.1038/4322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020567316
72 https://doi.org/10.1038/4322
73 rdf:type schema:CreativeWork
74 sg:pub.10.1038/86701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046501493
75 https://doi.org/10.1038/86701
76 rdf:type schema:CreativeWork
77 sg:pub.10.1038/sj.gt.3300601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043341032
78 https://doi.org/10.1038/sj.gt.3300601
79 rdf:type schema:CreativeWork
80 sg:pub.10.1038/sj.gt.3301414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052794585
81 https://doi.org/10.1038/sj.gt.3301414
82 rdf:type schema:CreativeWork
83 https://doi.org/10.1001/jama.285.5.545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026117182
84 rdf:type schema:CreativeWork
85 https://doi.org/10.1016/s0378-1119(99)00522-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004060752
86 rdf:type schema:CreativeWork
87 https://doi.org/10.1021/bi9921891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055218649
88 rdf:type schema:CreativeWork
89 https://doi.org/10.1073/pnas.85.2.524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015722860
90 rdf:type schema:CreativeWork
91 https://doi.org/10.1073/pnas.92.18.8298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011489267
92 rdf:type schema:CreativeWork
93 https://doi.org/10.1073/pnas.96.18.10349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033560585
94 rdf:type schema:CreativeWork
95 https://doi.org/10.1073/pnas.97.10.5363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052768417
96 rdf:type schema:CreativeWork
97 https://doi.org/10.1074/jbc.274.17.11541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041786503
98 rdf:type schema:CreativeWork
99 https://doi.org/10.1093/hmg/4.11.2081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059645238
100 rdf:type schema:CreativeWork
101 https://doi.org/10.1093/nar/16.3.791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046629961
102 rdf:type schema:CreativeWork
103 https://doi.org/10.1093/nar/27.4.1176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017866183
104 rdf:type schema:CreativeWork
105 https://doi.org/10.1093/nar/28.21.4332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040730547
106 rdf:type schema:CreativeWork
107 https://doi.org/10.1093/nar/29.20.4238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046383039
108 rdf:type schema:CreativeWork
109 https://doi.org/10.1126/science.270.5235.404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062551465
110 rdf:type schema:CreativeWork
111 https://doi.org/10.1126/science.273.5280.1386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062554059
112 rdf:type schema:CreativeWork
113 https://doi.org/10.1126/science.290.5491.530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062571805
114 rdf:type schema:CreativeWork
115 https://www.grid.ac/institutes/grid.33489.35 schema:Organization
 




Preview window. Press ESC to close (or click here)


...