Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues


Ontology type: sgo:Patent     


Patent Info

DATE

2007-04-03T00:00

AUTHORS

David A. Tirrell , Kristi Lynn Kiick

ABSTRACT

Methods for producing modified polypeptides containing amino acid analogues are disclosed, as well as compositions comprising purified dihydrofolate reductase polypeptides, produced by the methods of the invention. In certain aspects, methionine residues of the compositions are replaced with homoallyglycine, homoproparglycine, norvaline, norleucine, cis-crotyiglycine, trans-crotylglycine, 2-aminoheptanoic acid, 2-butynyiglycine and allyglycine.

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