Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices


Ontology type: sgo:Patent     


Patent Info

DATE

2007-03-20T00:00

AUTHORS

Mark J. Pykett , Michael Rosenzweig , David T. Scadden , Mark C. Poznansky

ABSTRACT

The invention relates to a method for lymphoid tissue-specific cell production from hematopoietic progenitor cells in unique, three-dimensional culture devices, in the presence of antigen presenting cells and lymphoreticular stromal cells, and in the absence of exogenously added growth factors. The resulting lymphoid tissue-specific cells may be isolated at any sequential stage of differentiation and further expanded. The lymphoid tissue-specific cells also may be genetically altered at any stage of the process. More... »

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