Inhibition of cell motility and angiogenesis by inhibitors of Grb2-SH2-domain


Ontology type: sgo:Patent     


Patent Info

DATE

2006-11-07T00:00

AUTHORS

BOTTARO DONALD P , ATABEY SAFIYE N , SORIANO JESUS V , BRECKENRIDGE DIANE E , YAO ZHU-JUN , GAO YANG , BURKE JR TERRENCE R

ABSTRACT

Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The present invention also provides a method of inhibiting angiogenesis. The methods of the present invention employ peptides such as phosphotyrosyl mimetics. The present invention further provides methods of preventing and/or treating diseases, disorders, states, or conditions such as cancer, particularly metastatic cancer comprising administering to a mammal of interest one or more peptides of the present invention. Also disclosed are methods of blocking HGF, VEGF, or bFGF-stimulated migration, cell proliferation, and formation of capillary-like structures More... »

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