Antibodies to JTT-1 protein, cells secreting such antibodies, and methods of making such antibodies


Ontology type: sgo:Patent     


Patent Info

DATE

2006-04-18T00:00

AUTHORS

Takuya Tamatani , Katsunari Tezuka

ABSTRACT

A cell surface molecule that is expressed specifically in thymocytes, lymphocytes activated by ConA-stimulation, and peripheral blood lymphocytes. This molecule is involved in signal transmission of the secondary signal (costimulatory signal) essential for the activation of lymphocytes such as T cells and regulates functions of activated lymphocytes such as activated T cells. Disclosed are an antibody or a portion thereof, which binds to a polypeptide of the cell surface molecule, a polypeptide fragment thereof, or a fusion polypeptide comprising the fragment; a cell secreting the antibody or its portion; a pharmaceutical composition comprising the antibody; and methods of using the compositions for therapeutic, diagnostic and/or experimental purpose. More... »

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