Detection of modulator of enzyme activity; obtain cells, incubate with modulator, monitor adjustment in enzyme activity, adjustment in activity indicates ...


Ontology type: sgo:Patent     


Patent Info

DATE

2005-09-13T00:00

AUTHORS

DAVIS ROGER J , FLAVELL RICHARD A , RAKIC PASKO , WHITMARSH ALAN J , KUAN CHIA-YI , YANG DEREK DI

ABSTRACT

The c-Jun NH2-terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene that encodes the neuronal isoform JNK3. It was found that JNK3 is required for the normal response to seizure activity. Methods of screening for molecules and compounds that decrease JNK3 expression or activity are described. Such molecules or compounds are useful for treating disorders involving excitotoxicity such as seizure disorders, Alzheimer's disease, Huntington disease, Parkinson's disease, and ischaemia. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "DAVIS ROGER J", 
        "type": "Person"
      }, 
      {
        "name": "FLAVELL RICHARD A", 
        "type": "Person"
      }, 
      {
        "name": "RAKIC PASKO", 
        "type": "Person"
      }, 
      {
        "name": "WHITMARSH ALAN J", 
        "type": "Person"
      }, 
      {
        "name": "KUAN CHIA-YI", 
        "type": "Person"
      }, 
      {
        "name": "YANG DEREK DI", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/369156a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029771272", 
          "https://doi.org/10.1038/369156a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001090050063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016860240", 
          "https://doi.org/10.1007/s001090050063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/385350a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045861763", 
          "https://doi.org/10.1038/385350a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/39899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035322653", 
          "https://doi.org/10.1038/39899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/372794a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012539120", 
          "https://doi.org/10.1038/372794a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/384368a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051289350", 
          "https://doi.org/10.1038/384368a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/365179a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009910352", 
          "https://doi.org/10.1038/365179a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-09-13T00:00", 
    "description": "

The c-Jun NH2-terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene that encodes the neuronal isoform JNK3. It was found that JNK3 is required for the normal response to seizure activity. Methods of screening for molecules and compounds that decrease JNK3 expression or activity are described. Such molecules or compounds are useful for treating disorders involving excitotoxicity such as seizure disorders, Alzheimer's disease, Huntington disease, Parkinson's disease, and ischaemia.

", "endDate": "2018-10-02", "id": "sg:patent.US-6943000-B2", "name": "Detection of modulator of enzyme activity; obtain cells, incubate with modulator, monitor adjustment in enzyme activity, adjustment in activity indicates modulator", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.266684.8", "type": "Organization" }, { "id": "http://www.grid.ac/institutes/grid.47100.32", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-6943000-B2" ], "sdDataset": "patents", "sdDatePublished": "2022-08-04T17:25", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/patent/patent_37.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-6943000-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-6943000-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-6943000-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-6943000-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

76 TRIPLES      15 PREDICATES      24 URIs      9 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-6943000-B2 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author Ndfaaa92d8e5b41f8a59666524245de74
4 schema:citation sg:pub.10.1007/s001090050063
5 sg:pub.10.1038/365179a0
6 sg:pub.10.1038/369156a0
7 sg:pub.10.1038/372794a0
8 sg:pub.10.1038/384368a0
9 sg:pub.10.1038/385350a0
10 sg:pub.10.1038/39899
11 schema:datePublished 2005-09-13T00:00
12 schema:description <p num="p-0001">The c-Jun NH<sub>2</sub>-terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene that encodes the neuronal isoform JNK3. It was found that JNK3 is required for the normal response to seizure activity. Methods of screening for molecules and compounds that decrease JNK3 expression or activity are described. Such molecules or compounds are useful for treating disorders involving excitotoxicity such as seizure disorders, Alzheimer's disease, Huntington disease, Parkinson's disease, and ischaemia.</p>
13 schema:endDate 2018-10-02
14 schema:name Detection of modulator of enzyme activity; obtain cells, incubate with modulator, monitor adjustment in enzyme activity, adjustment in activity indicates modulator
15 schema:recipient grid-institutes:grid.266684.8
16 grid-institutes:grid.47100.32
17 schema:sameAs https://app.dimensions.ai/details/patent/US-6943000-B2
18 schema:sdDatePublished 2022-08-04T17:25
19 schema:sdLicense https://scigraph.springernature.com/explorer/license/
20 schema:sdPublisher Nda127a1f907b49a3ac99300e6e023a10
21 sgo:license sg:explorer/license/
22 sgo:sdDataset patents
23 rdf:type sgo:Patent
24 N2050994dc96e403b83fd4de602cc70a2 schema:name YANG DEREK DI
25 rdf:type schema:Person
26 N3030e766bd754933aa4119d07f55ef5e schema:name KUAN CHIA-YI
27 rdf:type schema:Person
28 N52d4bae9205f4be6b3efb34dde62fb48 rdf:first N2050994dc96e403b83fd4de602cc70a2
29 rdf:rest rdf:nil
30 N58ddc91ac31f4f28a5f397ba09d4154f rdf:first N754a33a67b844c0986e5e2cd16475ca6
31 rdf:rest N913427fec6374331b77c00cc7eb1d2d1
32 N5e8ee66de1914efa9c0623163db03101 schema:name FLAVELL RICHARD A
33 rdf:type schema:Person
34 N717a2200953a4eb887436ba34e5078a5 rdf:first N3030e766bd754933aa4119d07f55ef5e
35 rdf:rest N52d4bae9205f4be6b3efb34dde62fb48
36 N754a33a67b844c0986e5e2cd16475ca6 schema:name RAKIC PASKO
37 rdf:type schema:Person
38 N7bbbaf855e004cf883cf2abe170860fd rdf:first N5e8ee66de1914efa9c0623163db03101
39 rdf:rest N58ddc91ac31f4f28a5f397ba09d4154f
40 N8d3f6547d9234f0fa517f7799468225b schema:name DAVIS ROGER J
41 rdf:type schema:Person
42 N913427fec6374331b77c00cc7eb1d2d1 rdf:first Nb0920116c585469c9f3af745673cfc81
43 rdf:rest N717a2200953a4eb887436ba34e5078a5
44 Nb0920116c585469c9f3af745673cfc81 schema:name WHITMARSH ALAN J
45 rdf:type schema:Person
46 Nda127a1f907b49a3ac99300e6e023a10 schema:name Springer Nature - SN SciGraph project
47 rdf:type schema:Organization
48 Ndfaaa92d8e5b41f8a59666524245de74 rdf:first N8d3f6547d9234f0fa517f7799468225b
49 rdf:rest N7bbbaf855e004cf883cf2abe170860fd
50 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
51 rdf:type schema:DefinedTerm
52 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
53 rdf:type schema:DefinedTerm
54 sg:pub.10.1007/s001090050063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016860240
55 https://doi.org/10.1007/s001090050063
56 rdf:type schema:CreativeWork
57 sg:pub.10.1038/365179a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009910352
58 https://doi.org/10.1038/365179a0
59 rdf:type schema:CreativeWork
60 sg:pub.10.1038/369156a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029771272
61 https://doi.org/10.1038/369156a0
62 rdf:type schema:CreativeWork
63 sg:pub.10.1038/372794a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012539120
64 https://doi.org/10.1038/372794a0
65 rdf:type schema:CreativeWork
66 sg:pub.10.1038/384368a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051289350
67 https://doi.org/10.1038/384368a0
68 rdf:type schema:CreativeWork
69 sg:pub.10.1038/385350a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045861763
70 https://doi.org/10.1038/385350a0
71 rdf:type schema:CreativeWork
72 sg:pub.10.1038/39899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035322653
73 https://doi.org/10.1038/39899
74 rdf:type schema:CreativeWork
75 grid-institutes:grid.266684.8 schema:Organization
76 grid-institutes:grid.47100.32 schema:Organization
 




Preview window. Press ESC to close (or click here)


...