Targeted chromosomal genomic alterations with modified single stranded oligonucleotides


Ontology type: sgo:Patent     


Patent Info

DATE

2005-08-30T00:00

AUTHORS

Eric B. Kmiec , Howard B. Gamper , Michael C. Rice

ABSTRACT

Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2′-O-Me base analogs.

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