Inhibitors of the EGF-receptor tyrosine kinase and methods for their use


Ontology type: sgo:Patent     


Patent Info

DATE

2005-03-08T00:00

AUTHORS

UCKUN FATIH M , ZHENG YAGUO , GHOSH SUTAPA

ABSTRACT

Novel compounds and pharmaceutical compositions useful as EGFR tyrosine kinase inhibitors. Methods of the invention include administration of the EGFR TK inhibitors to treat diseases characterized by enhanced expression of EGF, including cancers, particularly breast cancer. Additionally, a homology model representing the structure of EGFR kinase domain is provided, which model is useful for the rationally design and screening of compounds predicted to bind favorably to EGFR and to inhibit EGFR TK. More... »

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