2004-11-30T00:00
AUTHORSNICOLAIDES NICHOLAS C , SASS PHILIP M , GRASSO LUIGI , VOGELSTEIN BERT , KINZLER KENNETH W
ABSTRACTDominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. The enhanced rate of mutation can be further augmented using mutagens. Moreover, the hypermutability of mismatch repair deficient cells can be remedied to stabilize cells or mammals with useful mutations. More... »
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"type": "DefinedTerm"
}
],
"author": [
{
"name": "NICOLAIDES NICHOLAS C",
"type": "Person"
},
{
"name": "SASS PHILIP M",
"type": "Person"
},
{
"name": "GRASSO LUIGI",
"type": "Person"
},
{
"name": "VOGELSTEIN BERT",
"type": "Person"
},
{
"name": "KINZLER KENNETH W",
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/368258a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040515741",
"https://doi.org/10.1038/368258a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm0296-169",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028904279",
"https://doi.org/10.1038/nm0296-169"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/365274a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019075047",
"https://doi.org/10.1038/365274a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/71643",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005939765",
"https://doi.org/10.1038/71643"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/371075a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024767107",
"https://doi.org/10.1038/371075a0"
],
"type": "CreativeWork"
}
],
"datePublished": "2004-11-30T00:00",
"description": "Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. The enhanced rate of mutation can be further augmented using mutagens. Moreover, the hypermutability of mismatch repair deficient cells can be remedied to stabilize cells or mammals with useful mutations.
",
"endDate": "2021-10-18",
"id": "sg:patent.US-6825038-B2",
"name": "Method for generating hypermutable organisms",
"recipient": [
{
"id": "http://www.grid.ac/institutes/grid.21107.35",
"type": "Organization"
},
{
"id": "http://www.grid.ac/institutes/grid.418767.b",
"type": "Organization"
}
],
"sameAs": [
"https://app.dimensions.ai/details/patent/US-6825038-B2"
],
"sdDataset": "patents",
"sdDatePublished": "2022-06-01T22:39",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/patent/patent_0.jsonl",
"type": "Patent"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-6825038-B2'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-6825038-B2'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-6825038-B2'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-6825038-B2'
This table displays all metadata directly associated to this object as RDF triples.
67 TRIPLES
15 PREDICATES
23 URIs
9 LITERALS
2 BLANK NODES