Method for generating hypermutable organisms


Ontology type: sgo:Patent     


Patent Info

DATE

2004-11-30T00:00

AUTHORS

NICOLAIDES NICHOLAS C , SASS PHILIP M , GRASSO LUIGI , VOGELSTEIN BERT , KINZLER KENNETH W

ABSTRACT

Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. The enhanced rate of mutation can be further augmented using mutagens. Moreover, the hypermutability of mismatch repair deficient cells can be remedied to stabilize cells or mammals with useful mutations. More... »

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