Nanoparticles having oligonucleotides attached thereto and uses therefor


Ontology type: sgo:Patent     


Patent Info

DATE

2004-11-16T00:00

AUTHORS

Chad A. Mirkin , Robert L. Letsinger , Robert C. Mucic , James J. Storhoff , Robert Elghanian , Thomas A. Taton

ABSTRACT

The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3021", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Chad A. Mirkin", 
        "type": "Person"
      }, 
      {
        "name": "Robert L. Letsinger", 
        "type": "Person"
      }, 
      {
        "name": "Robert C. Mucic", 
        "type": "Person"
      }, 
      {
        "name": "James J. Storhoff", 
        "type": "Person"
      }, 
      {
        "name": "Robert Elghanian", 
        "type": "Person"
      }, 
      {
        "name": "Thomas A. Taton", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/nar/30.7.1558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000482521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la950776r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000739633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la950776r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000739633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bioeng.3.1.335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002076643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.277.5329.1078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010525136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bb.23.060194.002545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011235010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/382609a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013811778", 
          "https://doi.org/10.1038/382609a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(77)90182-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015148835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adma.19950070907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017153621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adma.19950070907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017153621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/382607a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030717946", 
          "https://doi.org/10.1038/382607a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(84)90518-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034491884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/350631a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034775610", 
          "https://doi.org/10.1038/350631a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja010437m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041739689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja010437m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041739689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/cc9960000555", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042820289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0040-4039(96)01381-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047699773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1296-441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051306917", 
          "https://doi.org/10.1038/ng1296-441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/23.4.696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051767673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac00100a008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054971987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc990152n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055156524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc990152n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055156524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00059a003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055159174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00237a005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055166521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00250a005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055167025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cen-v074n034.p006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055360711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00069a076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055704099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00081a069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055705244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00198a063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055713562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00242a020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055717014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja0177915", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055818938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja0177915", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055818938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja983183m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055870784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la00018a030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056137463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la981729c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056170776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la981729c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056170776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8475384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062655745"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-11-16T00:00", 
    "description": "

The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

", "id": "sg:patent.US-6818753-B2", "keywords": [ "nanoparticles", "oligonucleotides", "therefor", "invention", "method", "nucleic acid", "particle", "embodiment", "sequence", "portion", "detectable change", "color change", "hybridization", "composition", "kit", "conjugate", "Nanostructures", "nanofabrication" ], "name": "Nanoparticles having oligonucleotides attached thereto and uses therefor", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.422095.8", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-6818753-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:28", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_03148.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-6818753-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-6818753-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-6818753-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-6818753-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

157 TRIPLES      15 PREDICATES      63 URIs      26 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-6818753-B2 schema:about anzsrc-for:3021
2 schema:author N2018179526dd4095816c519ccb85f3c9
3 schema:citation sg:pub.10.1038/350631a0
4 sg:pub.10.1038/382607a0
5 sg:pub.10.1038/382609a0
6 sg:pub.10.1038/ng1296-441
7 https://doi.org/10.1002/adma.19950070907
8 https://doi.org/10.1016/0003-2697(84)90518-9
9 https://doi.org/10.1016/0040-4039(96)01381-0
10 https://doi.org/10.1016/0092-8674(77)90182-9
11 https://doi.org/10.1021/ac00100a008
12 https://doi.org/10.1021/bc990152n
13 https://doi.org/10.1021/bi00059a003
14 https://doi.org/10.1021/bi00237a005
15 https://doi.org/10.1021/bi00250a005
16 https://doi.org/10.1021/cen-v074n034.p006
17 https://doi.org/10.1021/ja00069a076
18 https://doi.org/10.1021/ja00081a069
19 https://doi.org/10.1021/ja00198a063
20 https://doi.org/10.1021/ja00242a020
21 https://doi.org/10.1021/ja010437m
22 https://doi.org/10.1021/ja0177915
23 https://doi.org/10.1021/ja983183m
24 https://doi.org/10.1021/la00018a030
25 https://doi.org/10.1021/la950776r
26 https://doi.org/10.1021/la981729c
27 https://doi.org/10.1039/cc9960000555
28 https://doi.org/10.1093/nar/23.4.696
29 https://doi.org/10.1093/nar/30.7.1558
30 https://doi.org/10.1126/science.277.5329.1078
31 https://doi.org/10.1126/science.8475384
32 https://doi.org/10.1146/annurev.bb.23.060194.002545
33 https://doi.org/10.1146/annurev.bioeng.3.1.335
34 schema:datePublished 2004-11-16T00:00
35 schema:description <p>The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.</p>
36 schema:keywords Nanostructures
37 color change
38 composition
39 conjugate
40 detectable change
41 embodiment
42 hybridization
43 invention
44 kit
45 method
46 nanofabrication
47 nanoparticles
48 nucleic acid
49 oligonucleotides
50 particle
51 portion
52 sequence
53 therefor
54 schema:name Nanoparticles having oligonucleotides attached thereto and uses therefor
55 schema:recipient https://www.grid.ac/institutes/grid.422095.8
56 schema:sameAs https://app.dimensions.ai/details/patent/US-6818753-B2
57 schema:sdDatePublished 2019-04-18T10:28
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher Nd6ee9c42c830451b92aef95618c062fa
60 sgo:license sg:explorer/license/
61 sgo:sdDataset patents
62 rdf:type sgo:Patent
63 N2018179526dd4095816c519ccb85f3c9 rdf:first N453c0ef7cfc249a9abd3395fab9c3c52
64 rdf:rest N8c8bc1b75f2c4970b6771335cf9de69a
65 N453c0ef7cfc249a9abd3395fab9c3c52 schema:name Chad A. Mirkin
66 rdf:type schema:Person
67 N48dcb168ba094b6da5d515c31d7357e5 rdf:first N98450f8ad2d240d885726d096a7facb6
68 rdf:rest rdf:nil
69 N692d3f63af75418b9c1575bb9a1bb9d8 rdf:first Nacb763d20e1b48bba657ab9c2b8971a7
70 rdf:rest Na2673f9cbf3848a78db5c86341918a88
71 N77d43c9ec34640a49a1071dccc43742c rdf:first Nbcb6575869f44fb3b4134f2d58e38543
72 rdf:rest N48dcb168ba094b6da5d515c31d7357e5
73 N8c8bc1b75f2c4970b6771335cf9de69a rdf:first Ne7af4c53ffc641da906a542086596624
74 rdf:rest N692d3f63af75418b9c1575bb9a1bb9d8
75 N98450f8ad2d240d885726d096a7facb6 schema:name Thomas A. Taton
76 rdf:type schema:Person
77 Na2673f9cbf3848a78db5c86341918a88 rdf:first Nf6cc23efcca24f03a4490d52da1aaad0
78 rdf:rest N77d43c9ec34640a49a1071dccc43742c
79 Nacb763d20e1b48bba657ab9c2b8971a7 schema:name Robert C. Mucic
80 rdf:type schema:Person
81 Nbcb6575869f44fb3b4134f2d58e38543 schema:name Robert Elghanian
82 rdf:type schema:Person
83 Nd6ee9c42c830451b92aef95618c062fa schema:name Springer Nature - SN SciGraph project
84 rdf:type schema:Organization
85 Ne7af4c53ffc641da906a542086596624 schema:name Robert L. Letsinger
86 rdf:type schema:Person
87 Nf6cc23efcca24f03a4490d52da1aaad0 schema:name James J. Storhoff
88 rdf:type schema:Person
89 anzsrc-for:3021 schema:inDefinedTermSet anzsrc-for:
90 rdf:type schema:DefinedTerm
91 sg:pub.10.1038/350631a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034775610
92 https://doi.org/10.1038/350631a0
93 rdf:type schema:CreativeWork
94 sg:pub.10.1038/382607a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030717946
95 https://doi.org/10.1038/382607a0
96 rdf:type schema:CreativeWork
97 sg:pub.10.1038/382609a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013811778
98 https://doi.org/10.1038/382609a0
99 rdf:type schema:CreativeWork
100 sg:pub.10.1038/ng1296-441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051306917
101 https://doi.org/10.1038/ng1296-441
102 rdf:type schema:CreativeWork
103 https://doi.org/10.1002/adma.19950070907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017153621
104 rdf:type schema:CreativeWork
105 https://doi.org/10.1016/0003-2697(84)90518-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034491884
106 rdf:type schema:CreativeWork
107 https://doi.org/10.1016/0040-4039(96)01381-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047699773
108 rdf:type schema:CreativeWork
109 https://doi.org/10.1016/0092-8674(77)90182-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015148835
110 rdf:type schema:CreativeWork
111 https://doi.org/10.1021/ac00100a008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054971987
112 rdf:type schema:CreativeWork
113 https://doi.org/10.1021/bc990152n schema:sameAs https://app.dimensions.ai/details/publication/pub.1055156524
114 rdf:type schema:CreativeWork
115 https://doi.org/10.1021/bi00059a003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055159174
116 rdf:type schema:CreativeWork
117 https://doi.org/10.1021/bi00237a005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055166521
118 rdf:type schema:CreativeWork
119 https://doi.org/10.1021/bi00250a005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055167025
120 rdf:type schema:CreativeWork
121 https://doi.org/10.1021/cen-v074n034.p006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055360711
122 rdf:type schema:CreativeWork
123 https://doi.org/10.1021/ja00069a076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055704099
124 rdf:type schema:CreativeWork
125 https://doi.org/10.1021/ja00081a069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055705244
126 rdf:type schema:CreativeWork
127 https://doi.org/10.1021/ja00198a063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055713562
128 rdf:type schema:CreativeWork
129 https://doi.org/10.1021/ja00242a020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055717014
130 rdf:type schema:CreativeWork
131 https://doi.org/10.1021/ja010437m schema:sameAs https://app.dimensions.ai/details/publication/pub.1041739689
132 rdf:type schema:CreativeWork
133 https://doi.org/10.1021/ja0177915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055818938
134 rdf:type schema:CreativeWork
135 https://doi.org/10.1021/ja983183m schema:sameAs https://app.dimensions.ai/details/publication/pub.1055870784
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1021/la00018a030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056137463
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1021/la950776r schema:sameAs https://app.dimensions.ai/details/publication/pub.1000739633
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1021/la981729c schema:sameAs https://app.dimensions.ai/details/publication/pub.1056170776
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1039/cc9960000555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042820289
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1093/nar/23.4.696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051767673
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1093/nar/30.7.1558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000482521
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1126/science.277.5329.1078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010525136
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1126/science.8475384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062655745
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1146/annurev.bb.23.060194.002545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011235010
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1146/annurev.bioeng.3.1.335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002076643
156 rdf:type schema:CreativeWork
157 https://www.grid.ac/institutes/grid.422095.8 schema:Organization
 




Preview window. Press ESC to close (or click here)


...