Vascular endothelial growth factor C (VEGF-C) protein and gene mutants thereof, and uses thereof


Ontology type: sgo:Patent     


Patent Info

DATE

2004-11-16T00:00

AUTHORS

Kari Alitalo , Vladimir Joukov

ABSTRACT

Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that are VEGF or VEGF-C inhibitors; polynucleotides encoding the polypeptides; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the polypeptides. More... »

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