Retroviral vectors comprising a functional splice donor site and a functional splice acceptor site


Ontology type: sgo:Patent     


Patent Info

DATE

2004-10-26T00:00

AUTHORS

Christopher Robert Bebbington , Susan Mary Kingsman , Mark Uden , Alan John Kingsman , Kyriacos Mitrophanos

ABSTRACT

A retroviral vector is described. The retroviral vector comprises a functional splice donor site and a functional splice acceptor site; wherein the functional splice donor site and the functional splice acceptor site flank a first nucleotide sequence of interest (“NOI”); wherein the functional splice donor site is upstream of the functional splice acceptor site; wherein the retroviral vector is derived from a retroviral pro-vector; wherein the retroviral pro-vector comprises a first nucleotide sequence (“NS”) capable of yielding the functional splice donor site and a second NS capable of yielding the functional splice acceptor site; wherein the first NS is downstream of the second NS; such that the retroviral vector is formed as a result of reverse transcription of the retroviral pro-vector. More... »

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