HIV-1, cancer; aminobutyric acid, 2,4- diaminobutyric acid, beta-alanine, dimethylaminopropylamide, N-methylimidazole, N-methylpyrrole


Ontology type: sgo:Patent     


Patent Info

DATE

2003-12-09T00:00

AUTHORS

GOTTESFELD JOEL M , DERVAN PETER B , MOSIER DONALD E , BAIRD ELDON E

ABSTRACT

The invention provides polyamides suitable for modulating cellular or viral gene expression by binding to an identified target DNA sequence adjacent to the binding site of a minor groove transcription factor protein. The polyamides of the present invention are useful for the treatment of a human infected with a virus such as HIV-1. The polyamides of the present invention are also useful for the treatment of conditions, such as cancers, that result from the expression or over-expression of cellular genes, particularly oncogenes. More... »

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