Methods for generating hypermutable yeast


Ontology type: sgo:Patent     


Patent Info

DATE

2003-12-02T00:00

AUTHORS

NICOLAIDES NICHOLAS C , SASS PHILIP M , GRASSO LUIGI , VOGELSTEIN BERT , KINZLER KENNETH W

ABSTRACT

Yeast cells are mutagenized to obtain desirable mutants. Mutagenesis is mediated by a defective mismatch repair system which can be enhanced using conventional exogenously applied mutagens. Yeast cells with the defective mismatch repair system are hypermutable, but after selection of desired mutant yeast strains, they can be be rendered genetically stable by restoring the mismatch repair system to proper functionality. More... »

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