Method for screening compounds for the treatment of neoplasia


Ontology type: sgo:Patent     


Patent Info

DATE

2003-05-27T00:00

AUTHORS

WEINSTEIN I BERNARD , THOMPSON W JOSEPH , SOH JAE-WON , LIU LI , LI HAN

ABSTRACT

This invention provides a method to identify compounds potentially useful for the treatment and prevention of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with its ability to elevate JNK kinase activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibition, an ability to elevate JNK kinase activity, growth inhibition and apoptosis induction are desirable for the treatment of neoplasia. More... »

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