Preparation of non-human animals having chimeric livers for use of animal models for human liver toxins; immunocompetent animals are rendered ...


Ontology type: sgo:Patent     


Patent Info

DATE

2003-02-25T00:00

AUTHORS

WU GEORGE Y , WU CATHERINE H

ABSTRACT

The present invention relates to the preparation of non-human animals having chimeric livers, whereby some or substantially all of the hepatocytes present are human hepatocytes. It is based, at least in part, on the discovery that rats, tolerized in utero against human hepatocytes, were found to serve as long-term hosts for human hepatocytes introduced post-natally, and the introduced hepatocytes maintained their differentiated phenotype, as evidenced by continued production of human albumin. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "WU GEORGE Y", 
        "type": "Person"
      }, 
      {
        "name": "WU CATHERINE H", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/73187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018224457", 
          "https://doi.org/10.1038/73187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/172603a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025499224", 
          "https://doi.org/10.1038/172603a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0494-335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016499584", 
          "https://doi.org/10.1038/ng0494-335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/335796a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038379301", 
          "https://doi.org/10.1038/335796a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/337364a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035604737", 
          "https://doi.org/10.1038/337364a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-02-25T00:00", 
    "description": "

The present invention relates to the preparation of non-human animals having chimeric livers, whereby some or substantially all of the hepatocytes present are human hepatocytes. It is based, at least in part, on the discovery that rats, tolerized in utero against human hepatocytes, were found to serve as long-term hosts for human hepatocytes introduced post-natally, and the introduced hepatocytes maintained their differentiated phenotype, as evidenced by continued production of human albumin.

", "endDate": "2019-11-02", "id": "sg:patent.US-6525242-B1", "name": "Preparation of non-human animals having chimeric livers for use of animal models for human liver toxins; immunocompetent animals are rendered tolerant to human hepatocytes by cell or lysate administration during embryonic or neonate stage", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.63054.34", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-6525242-B1" ], "sdDataset": "patents", "sdDatePublished": "2022-09-02T16:21", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/patent/patent_50.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-6525242-B1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-6525242-B1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-6525242-B1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-6525242-B1'


 

This table displays all metadata directly associated to this object as RDF triples.

50 TRIPLES      15 PREDICATES      21 URIs      9 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-6525242-B1 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N76b683dc4cb24d96bb507ad24a1d2a39
4 schema:citation sg:pub.10.1038/172603a0
5 sg:pub.10.1038/335796a0
6 sg:pub.10.1038/337364a0
7 sg:pub.10.1038/73187
8 sg:pub.10.1038/ng0494-335
9 schema:datePublished 2003-02-25T00:00
10 schema:description <p>The present invention relates to the preparation of non-human animals having chimeric livers, whereby some or substantially all of the hepatocytes present are human hepatocytes. It is based, at least in part, on the discovery that rats, tolerized in utero against human hepatocytes, were found to serve as long-term hosts for human hepatocytes introduced post-natally, and the introduced hepatocytes maintained their differentiated phenotype, as evidenced by continued production of human albumin.</p>
11 schema:endDate 2019-11-02
12 schema:name Preparation of non-human animals having chimeric livers for use of animal models for human liver toxins; immunocompetent animals are rendered tolerant to human hepatocytes by cell or lysate administration during embryonic or neonate stage
13 schema:recipient grid-institutes:grid.63054.34
14 schema:sameAs https://app.dimensions.ai/details/patent/US-6525242-B1
15 schema:sdDatePublished 2022-09-02T16:21
16 schema:sdLicense https://scigraph.springernature.com/explorer/license/
17 schema:sdPublisher N5d4eeb8ed830431cabdc6459f0de0308
18 sgo:license sg:explorer/license/
19 sgo:sdDataset patents
20 rdf:type sgo:Patent
21 N18fa0b31938f44338e6e2f68bfbeb09a schema:name WU GEORGE Y
22 rdf:type schema:Person
23 N351c805ad461490aa9898ef37983025d schema:name WU CATHERINE H
24 rdf:type schema:Person
25 N5d4eeb8ed830431cabdc6459f0de0308 schema:name Springer Nature - SN SciGraph project
26 rdf:type schema:Organization
27 N76b683dc4cb24d96bb507ad24a1d2a39 rdf:first N18fa0b31938f44338e6e2f68bfbeb09a
28 rdf:rest Ne16fa307e1404c0a81afe2e95d3c92f8
29 Ne16fa307e1404c0a81afe2e95d3c92f8 rdf:first N351c805ad461490aa9898ef37983025d
30 rdf:rest rdf:nil
31 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
32 rdf:type schema:DefinedTerm
33 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
34 rdf:type schema:DefinedTerm
35 sg:pub.10.1038/172603a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025499224
36 https://doi.org/10.1038/172603a0
37 rdf:type schema:CreativeWork
38 sg:pub.10.1038/335796a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038379301
39 https://doi.org/10.1038/335796a0
40 rdf:type schema:CreativeWork
41 sg:pub.10.1038/337364a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035604737
42 https://doi.org/10.1038/337364a0
43 rdf:type schema:CreativeWork
44 sg:pub.10.1038/73187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018224457
45 https://doi.org/10.1038/73187
46 rdf:type schema:CreativeWork
47 sg:pub.10.1038/ng0494-335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016499584
48 https://doi.org/10.1038/ng0494-335
49 rdf:type schema:CreativeWork
50 grid-institutes:grid.63054.34 schema:Organization
 




Preview window. Press ESC to close (or click here)


...