Preparation of non-human animals having chimeric livers for use of animal models for human liver toxins; immunocompetent animals are rendered ...


Ontology type: sgo:Patent     


Patent Info

DATE

2003-02-25T00:00

AUTHORS

WU GEORGE Y , WU CATHERINE H

ABSTRACT

The present invention relates to the preparation of non-human animals having chimeric livers, whereby some or substantially all of the hepatocytes present are human hepatocytes. It is based, at least in part, on the discovery that rats, tolerized in utero against human hepatocytes, were found to serve as long-term hosts for human hepatocytes introduced post-natally, and the introduced hepatocytes maintained their differentiated phenotype, as evidenced by continued production of human albumin. More... »

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