Which Is Activated By A Stimulus Induced By Tumor Necrosis Factor-Alpha And/Or By A Stimulation Of Fas Antigen, And Activates ...


Ontology type: sgo:Patent     


Patent Info

DATE

2002-10-15T00:00

AUTHORS

NISHIDA EISUKE , MORIGUCHI TETSUO , MATSUZAKI OSAMU

ABSTRACT

Disclosed is a substantially pure MAPK (mitogen-activated protein kinase) kinase derived from a vertebrate, which is activated by a stimulus induced by TNF-alpha and/or by a stimulation of Fas antigen, and which in turn activates SAPK/JNK, but does not activate p38; and also disclosed is a DNA coding for the same. By the use of the novel MAPK kinase and the DNA coding for the same of the present invention, it has become possible to screen a novel substance having the capability to treat or prevent diseases resulting from an excess activation or inhibition of a MAP kinase cascade, and also to provide a diagnostic reagent for such diseases. In addition, the DNA of the present invention encoding the MAPK kinase can be used as a gene source for gene therapy. Further disclosed are a replicable recombinant DNA which comprises a replicable expression vector and, operably inserted therein, the above-mentioned DNA; a cell of a microorganism or cell culture, which is transformed with the above-mentioned replicable recombinant DNA; a polypeptide of a dominant negative form of the above-mentioned MAPK kinase and a DNA coding for the same; and an antibody capable of binding specifically to the above-mentioned MAPK kinase. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "NISHIDA EISUKE", 
        "type": "Person"
      }, 
      {
        "name": "MORIGUCHI TETSUO", 
        "type": "Person"
      }, 
      {
        "name": "MATSUZAKI OSAMU", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/372794a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012539120", 
          "https://doi.org/10.1038/372794a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/372798a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022511929", 
          "https://doi.org/10.1038/372798a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-10-15T00:00", 
    "description": "

Disclosed is a substantially pure MAPK (mitogen-activated protein kinase) kinase derived from a vertebrate, which is activated by a stimulus induced by TNF-alpha and/or by a stimulation of Fas antigen, and which in turn activates SAPK/JNK, but does not activate p38; and also disclosed is a DNA coding for the same. By the use of the novel MAPK kinase and the DNA coding for the same of the present invention, it has become possible to screen a novel substance having the capability to treat or prevent diseases resulting from an excess activation or inhibition of a MAP kinase cascade, and also to provide a diagnostic reagent for such diseases. In addition, the DNA of the present invention encoding the MAPK kinase can be used as a gene source for gene therapy. Further disclosed are a replicable recombinant DNA which comprises a replicable expression vector and, operably inserted therein, the above-mentioned DNA; a cell of a microorganism or cell culture, which is transformed with the above-mentioned replicable recombinant DNA; a polypeptide of a dominant negative form of the above-mentioned MAPK kinase and a DNA coding for the same; and an antibody capable of binding specifically to the above-mentioned MAPK kinase.

", "endDate": "2018-07-03", "id": "sg:patent.US-6465618-B1", "name": "WHICH IS ACTIVATED BY A STIMULUS INDUCED BY TUMOR NECROSIS FACTOR-ALPHA AND/OR BY A STIMULATION OF FAS ANTIGEN, AND ACTIVATES STRESS ACTIVATED PROTEIN KINASE(SAPK)/C-JUN N-TERMINAL KINASE (JNK) BUT DOES NOT ACTIVATE P38", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.410859.1", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-6465618-B1" ], "sdDataset": "patents", "sdDatePublished": "2022-09-02T16:21", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/patent/patent_12.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-6465618-B1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-6465618-B1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-6465618-B1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-6465618-B1'


 

This table displays all metadata directly associated to this object as RDF triples.

45 TRIPLES      15 PREDICATES      19 URIs      9 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-6465618-B1 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 anzsrc-for:0604
4 schema:author Nd9886b0b246045239063202a9df301d8
5 schema:citation sg:pub.10.1038/372794a0
6 sg:pub.10.1038/372798a0
7 schema:datePublished 2002-10-15T00:00
8 schema:description <p>Disclosed is a substantially pure MAPK (mitogen-activated protein kinase) kinase derived from a vertebrate, which is activated by a stimulus induced by TNF-alpha and/or by a stimulation of Fas antigen, and which in turn activates SAPK/JNK, but does not activate p38; and also disclosed is a DNA coding for the same. By the use of the novel MAPK kinase and the DNA coding for the same of the present invention, it has become possible to screen a novel substance having the capability to treat or prevent diseases resulting from an excess activation or inhibition of a MAP kinase cascade, and also to provide a diagnostic reagent for such diseases. In addition, the DNA of the present invention encoding the MAPK kinase can be used as a gene source for gene therapy. Further disclosed are a replicable recombinant DNA which comprises a replicable expression vector and, operably inserted therein, the above-mentioned DNA; a cell of a microorganism or cell culture, which is transformed with the above-mentioned replicable recombinant DNA; a polypeptide of a dominant negative form of the above-mentioned MAPK kinase and a DNA coding for the same; and an antibody capable of binding specifically to the above-mentioned MAPK kinase.</p>
9 schema:endDate 2018-07-03
10 schema:name WHICH IS ACTIVATED BY A STIMULUS INDUCED BY TUMOR NECROSIS FACTOR-ALPHA AND/OR BY A STIMULATION OF FAS ANTIGEN, AND ACTIVATES STRESS ACTIVATED PROTEIN KINASE(SAPK)/C-JUN N-TERMINAL KINASE (JNK) BUT DOES NOT ACTIVATE P38
11 schema:recipient grid-institutes:grid.410859.1
12 schema:sameAs https://app.dimensions.ai/details/patent/US-6465618-B1
13 schema:sdDatePublished 2022-09-02T16:21
14 schema:sdLicense https://scigraph.springernature.com/explorer/license/
15 schema:sdPublisher Na7fa541e7bc24f11b47e5f4c90ec3367
16 sgo:license sg:explorer/license/
17 sgo:sdDataset patents
18 rdf:type sgo:Patent
19 N0fad438b738042f681ca64ef93daba2c schema:name NISHIDA EISUKE
20 rdf:type schema:Person
21 N546affa0e3704f65a60d846942a9333a rdf:first N694bc7317f5b49d39f126aa3a96da982
22 rdf:rest N8d305a4b52b3463980165b084bf6bc5f
23 N694bc7317f5b49d39f126aa3a96da982 schema:name MORIGUCHI TETSUO
24 rdf:type schema:Person
25 N8d305a4b52b3463980165b084bf6bc5f rdf:first Ne029290894654ca6a13ff04cc547a330
26 rdf:rest rdf:nil
27 Na7fa541e7bc24f11b47e5f4c90ec3367 schema:name Springer Nature - SN SciGraph project
28 rdf:type schema:Organization
29 Nd9886b0b246045239063202a9df301d8 rdf:first N0fad438b738042f681ca64ef93daba2c
30 rdf:rest N546affa0e3704f65a60d846942a9333a
31 Ne029290894654ca6a13ff04cc547a330 schema:name MATSUZAKI OSAMU
32 rdf:type schema:Person
33 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
34 rdf:type schema:DefinedTerm
35 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
36 rdf:type schema:DefinedTerm
37 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
38 rdf:type schema:DefinedTerm
39 sg:pub.10.1038/372794a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012539120
40 https://doi.org/10.1038/372794a0
41 rdf:type schema:CreativeWork
42 sg:pub.10.1038/372798a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022511929
43 https://doi.org/10.1038/372798a0
44 rdf:type schema:CreativeWork
45 grid-institutes:grid.410859.1 schema:Organization
 




Preview window. Press ESC to close (or click here)


...