Stimulate Phosphorylation And Activation Of Substrates Such As Atf2, Are Provided. The Polypeptides May Be Used, To Identify Antibodies


Ontology type: sgo:Patent     


Patent Info

DATE

2002-09-03T00:00

AUTHORS

STEIN BERND , YANG MARIA X H , YOUNG DAVID B

ABSTRACT

Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades. More... »

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