Modified enzymes and their use for peptide synthesis


Ontology type: sgo:Patent     


Patent Info

DATE

2002-05-28T00:00

AUTHORS

J. Bryan Jones

ABSTRACT

The present invention relates to modified enzymes with one or more amino acid residues from an enzyme being replaced by cysteine residues, where at least some of the cysteine residues are modified by replacing thiol hydrogen in the cysteine residue with a thiol side chain to form a modified enzyme, wherein the modified enzyme has high esterase and low amidase activity. Also, a method of producing the modified enzymes is provided. The present invention also relates to a method for using the modified enzymes in peptide synthesis. More... »

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