Method for producing immunoglobulins containing protection proteins in plants and their use


Ontology type: sgo:Patent     


Patent Info

DATE

2001-10-16T00:00

AUTHORS

Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner , Keith E. Mostov

ABSTRACT

The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment.The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules.The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated. More... »

Related SciGraph Publications

  • 1988-09. Regulation of a wheat promoter by abscisic acid in rice protoplasts in NATURE
  • 1984-03. The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains in NATURE
  • 1987-05. T-DNA is organized predominantly in inverted repeat structures in plants transformed with Agrobacterium tumefaciens C58 derivatives in MOLECULAR GENETICS AND GENOMICS
  • 1985-05. Direct gene transfer to cells of a graminaceous monocot in MOLECULAR GENETICS AND GENOMICS
  • 1985-05. Gene transfer to cereal cells mediated by protoplast transformation in MOLECULAR GENETICS AND GENOMICS
  • 1988-08. Stable Transformation of Soybean (Glycine Max) by Particle Acceleration in NATURE BIOTECHNOLOGY
  • 1986-02. Stable transformation of maize after gene transfer by electroporation in NATURE
  • 1987-01. Transgenic rye plants obtained by injecting DNA into young floral tillers in NATURE
  • 1986-12. Efficient Plant Regeneration from Rice Protoplasts Through Somatic Embryogenesis in NATURE BIOTECHNOLOGY
  • 1986-10. T-DNA structure in transgenic tobacco plants with multiple independent integration sites in MOLECULAR GENETICS AND GENOMICS
  • 1986-08. Expression of a foreign gene in callus derived from DNA-treated protoplasts of rice (Oryza sativa L.) in MOLECULAR GENETICS AND GENOMICS
  • 1984-09. Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins in NATURE
  • 1985-02. Identification of DNA sequences required for activity of the cauliflower mosaic virus 35S promoter in NATURE
  • 1987-05. High-velocity microprojectiles for delivering nucleic acids into living cells in NATURE
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2581", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2648", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "Andrew C. Hiatt", 
            "type": "Person"
          }, 
          {
            "name": "Julian K.-C. Ma", 
            "type": "Person"
          }, 
          {
            "name": "Thomas Lehner", 
            "type": "Person"
          }, 
          {
            "name": "Keith E. Mostov", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf00425499", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000368845", 
              "https://doi.org/10.1007/bf00425499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00425499", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000368845", 
              "https://doi.org/10.1007/bf00425499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/308037a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002290736", 
              "https://doi.org/10.1038/308037a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0888-923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002791856", 
              "https://doi.org/10.1038/nbt0888-923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/325274a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002903113", 
              "https://doi.org/10.1038/325274a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/335454a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003045984", 
              "https://doi.org/10.1038/335454a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/327070a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004294325", 
              "https://doi.org/10.1038/327070a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/327070a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004294325", 
              "https://doi.org/10.1038/327070a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.84.15.5345", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004576569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.mi.35.100181.002401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008198329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bp00011a011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012114987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830220920", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013812741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0962-8924(92)90036-m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016467806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.83.2.456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017716459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1.10.1183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017967255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00331617", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022012805", 
              "https://doi.org/10.1007/bf00331617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00331617", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022012805", 
              "https://doi.org/10.1007/bf00331617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-5793(92)80904-u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022870791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1286-1087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024414095", 
              "https://doi.org/10.1038/nbt1286-1087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02428030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026692189", 
              "https://doi.org/10.1007/bf02428030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02428030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026692189", 
              "https://doi.org/10.1007/bf02428030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1399-302x.1989.tb00243.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027740434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/311071a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030149230", 
              "https://doi.org/10.1038/311071a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-291x(89)92790-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034478654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.80.15.4803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035204516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/313810a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035513087", 
              "https://doi.org/10.1038/313810a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(81)90408-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036956949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830240120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037453655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.18.8348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041581209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/319791a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045509134", 
              "https://doi.org/10.1038/319791a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00330257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048143781", 
              "https://doi.org/10.1007/bf00330257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00330257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048143781", 
              "https://doi.org/10.1007/bf00330257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.86.10.3833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050847096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-5793(89)81034-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051284461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00330256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052000462", 
              "https://doi.org/10.1007/bf00330256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00330256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052000462", 
              "https://doi.org/10.1007/bf00330256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.85.22.8502", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053549828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0161-5890(73)90138-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054553240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0161-5890(73)90138-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054553240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.227.4691.1229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062529900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.236.4806.1259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062534237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.244.4901.174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062537666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.250.4983.959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062541055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2531466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062542740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2928780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062574307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7732380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062649108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1984.tb02201.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077183716"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2001-10-16T00:00", 
        "description": "

    The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment.

    The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules.

    The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.

    ", "id": "sg:patent.US-6303341-B1", "keywords": [ "method", "immunoglobulin", "protection", "plant", "invention", "useful therapeutic", "mucosal pathogen", "S. mutans", "mucosal environment", "improved method", "same cell", "component", "improved efficiency", "assembly", "high efficiency", "complex molecule", "cell", "plant cell", "additional property", "therapeutic antibody", "pathogen" ], "name": "Method for producing immunoglobulins containing protection proteins in plants and their use", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.423136.1", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-6303341-B1" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:27", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_03097.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-6303341-B1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-6303341-B1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-6303341-B1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-6303341-B1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    192 TRIPLES      15 PREDICATES      76 URIs      29 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-6303341-B1 schema:about anzsrc-for:2581
    2 anzsrc-for:2648
    3 schema:author Na0d759f76f234df4a0e7abf17ef4c3d6
    4 schema:citation sg:pub.10.1007/bf00330256
    5 sg:pub.10.1007/bf00330257
    6 sg:pub.10.1007/bf00331617
    7 sg:pub.10.1007/bf00425499
    8 sg:pub.10.1007/bf02428030
    9 sg:pub.10.1038/308037a0
    10 sg:pub.10.1038/311071a0
    11 sg:pub.10.1038/313810a0
    12 sg:pub.10.1038/319791a0
    13 sg:pub.10.1038/325274a0
    14 sg:pub.10.1038/327070a0
    15 sg:pub.10.1038/335454a0
    16 sg:pub.10.1038/nbt0888-923
    17 sg:pub.10.1038/nbt1286-1087
    18 https://doi.org/10.1002/eji.1830220920
    19 https://doi.org/10.1002/eji.1830240120
    20 https://doi.org/10.1002/j.1460-2075.1984.tb02201.x
    21 https://doi.org/10.1016/0006-291x(89)92790-3
    22 https://doi.org/10.1016/0014-5793(89)81034-8
    23 https://doi.org/10.1016/0014-5793(92)80904-u
    24 https://doi.org/10.1016/0092-8674(81)90408-6
    25 https://doi.org/10.1016/0161-5890(73)90138-7
    26 https://doi.org/10.1016/0962-8924(92)90036-m
    27 https://doi.org/10.1021/bp00011a011
    28 https://doi.org/10.1073/pnas.80.15.4803
    29 https://doi.org/10.1073/pnas.83.2.456
    30 https://doi.org/10.1073/pnas.84.15.5345
    31 https://doi.org/10.1073/pnas.85.22.8502
    32 https://doi.org/10.1073/pnas.86.10.3833
    33 https://doi.org/10.1073/pnas.91.18.8348
    34 https://doi.org/10.1101/gad.1.10.1183
    35 https://doi.org/10.1111/j.1399-302x.1989.tb00243.x
    36 https://doi.org/10.1126/science.227.4691.1229
    37 https://doi.org/10.1126/science.236.4806.1259
    38 https://doi.org/10.1126/science.244.4901.174
    39 https://doi.org/10.1126/science.250.4983.959
    40 https://doi.org/10.1126/science.2531466
    41 https://doi.org/10.1126/science.2928780
    42 https://doi.org/10.1126/science.7732380
    43 https://doi.org/10.1146/annurev.mi.35.100181.002401
    44 schema:datePublished 2001-10-16T00:00
    45 schema:description <p>The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as <i>S. mutans</i>. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment.</p><p>The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules.</p><p>The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.</p>
    46 schema:keywords S. mutans
    47 additional property
    48 assembly
    49 cell
    50 complex molecule
    51 component
    52 high efficiency
    53 immunoglobulin
    54 improved efficiency
    55 improved method
    56 invention
    57 method
    58 mucosal environment
    59 mucosal pathogen
    60 pathogen
    61 plant
    62 plant cell
    63 protection
    64 same cell
    65 therapeutic antibody
    66 useful therapeutic
    67 schema:name Method for producing immunoglobulins containing protection proteins in plants and their use
    68 schema:recipient https://www.grid.ac/institutes/grid.423136.1
    69 schema:sameAs https://app.dimensions.ai/details/patent/US-6303341-B1
    70 schema:sdDatePublished 2019-04-18T10:27
    71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    72 schema:sdPublisher N08bdeb29adcf4c00aea01d16ec7e227d
    73 sgo:license sg:explorer/license/
    74 sgo:sdDataset patents
    75 rdf:type sgo:Patent
    76 N08bdeb29adcf4c00aea01d16ec7e227d schema:name Springer Nature - SN SciGraph project
    77 rdf:type schema:Organization
    78 N16567de4be8149428614f4d38a083e97 schema:name Julian K.-C. Ma
    79 rdf:type schema:Person
    80 N1ac7b460d3264b6daec56386218ff291 schema:name Thomas Lehner
    81 rdf:type schema:Person
    82 N299b0fe09b3544f4bc35d2c01b0dbe60 rdf:first N16567de4be8149428614f4d38a083e97
    83 rdf:rest Nbbdedd1cc32040808025182e50ff10f9
    84 N6d3e5e2e08b64052acab5cfd7a20224e schema:name Andrew C. Hiatt
    85 rdf:type schema:Person
    86 N6ef9e293f0634324833f38f5f2afcb78 schema:name Keith E. Mostov
    87 rdf:type schema:Person
    88 Na0d759f76f234df4a0e7abf17ef4c3d6 rdf:first N6d3e5e2e08b64052acab5cfd7a20224e
    89 rdf:rest N299b0fe09b3544f4bc35d2c01b0dbe60
    90 Nbbdedd1cc32040808025182e50ff10f9 rdf:first N1ac7b460d3264b6daec56386218ff291
    91 rdf:rest Neb0e055213d24e76b9d54201e1671439
    92 Neb0e055213d24e76b9d54201e1671439 rdf:first N6ef9e293f0634324833f38f5f2afcb78
    93 rdf:rest rdf:nil
    94 anzsrc-for:2581 schema:inDefinedTermSet anzsrc-for:
    95 rdf:type schema:DefinedTerm
    96 anzsrc-for:2648 schema:inDefinedTermSet anzsrc-for:
    97 rdf:type schema:DefinedTerm
    98 sg:pub.10.1007/bf00330256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052000462
    99 https://doi.org/10.1007/bf00330256
    100 rdf:type schema:CreativeWork
    101 sg:pub.10.1007/bf00330257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048143781
    102 https://doi.org/10.1007/bf00330257
    103 rdf:type schema:CreativeWork
    104 sg:pub.10.1007/bf00331617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022012805
    105 https://doi.org/10.1007/bf00331617
    106 rdf:type schema:CreativeWork
    107 sg:pub.10.1007/bf00425499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000368845
    108 https://doi.org/10.1007/bf00425499
    109 rdf:type schema:CreativeWork
    110 sg:pub.10.1007/bf02428030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026692189
    111 https://doi.org/10.1007/bf02428030
    112 rdf:type schema:CreativeWork
    113 sg:pub.10.1038/308037a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002290736
    114 https://doi.org/10.1038/308037a0
    115 rdf:type schema:CreativeWork
    116 sg:pub.10.1038/311071a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030149230
    117 https://doi.org/10.1038/311071a0
    118 rdf:type schema:CreativeWork
    119 sg:pub.10.1038/313810a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035513087
    120 https://doi.org/10.1038/313810a0
    121 rdf:type schema:CreativeWork
    122 sg:pub.10.1038/319791a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045509134
    123 https://doi.org/10.1038/319791a0
    124 rdf:type schema:CreativeWork
    125 sg:pub.10.1038/325274a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002903113
    126 https://doi.org/10.1038/325274a0
    127 rdf:type schema:CreativeWork
    128 sg:pub.10.1038/327070a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004294325
    129 https://doi.org/10.1038/327070a0
    130 rdf:type schema:CreativeWork
    131 sg:pub.10.1038/335454a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003045984
    132 https://doi.org/10.1038/335454a0
    133 rdf:type schema:CreativeWork
    134 sg:pub.10.1038/nbt0888-923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002791856
    135 https://doi.org/10.1038/nbt0888-923
    136 rdf:type schema:CreativeWork
    137 sg:pub.10.1038/nbt1286-1087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024414095
    138 https://doi.org/10.1038/nbt1286-1087
    139 rdf:type schema:CreativeWork
    140 https://doi.org/10.1002/eji.1830220920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013812741
    141 rdf:type schema:CreativeWork
    142 https://doi.org/10.1002/eji.1830240120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037453655
    143 rdf:type schema:CreativeWork
    144 https://doi.org/10.1002/j.1460-2075.1984.tb02201.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1077183716
    145 rdf:type schema:CreativeWork
    146 https://doi.org/10.1016/0006-291x(89)92790-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034478654
    147 rdf:type schema:CreativeWork
    148 https://doi.org/10.1016/0014-5793(89)81034-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051284461
    149 rdf:type schema:CreativeWork
    150 https://doi.org/10.1016/0014-5793(92)80904-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1022870791
    151 rdf:type schema:CreativeWork
    152 https://doi.org/10.1016/0092-8674(81)90408-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036956949
    153 rdf:type schema:CreativeWork
    154 https://doi.org/10.1016/0161-5890(73)90138-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054553240
    155 rdf:type schema:CreativeWork
    156 https://doi.org/10.1016/0962-8924(92)90036-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1016467806
    157 rdf:type schema:CreativeWork
    158 https://doi.org/10.1021/bp00011a011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012114987
    159 rdf:type schema:CreativeWork
    160 https://doi.org/10.1073/pnas.80.15.4803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035204516
    161 rdf:type schema:CreativeWork
    162 https://doi.org/10.1073/pnas.83.2.456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017716459
    163 rdf:type schema:CreativeWork
    164 https://doi.org/10.1073/pnas.84.15.5345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004576569
    165 rdf:type schema:CreativeWork
    166 https://doi.org/10.1073/pnas.85.22.8502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053549828
    167 rdf:type schema:CreativeWork
    168 https://doi.org/10.1073/pnas.86.10.3833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050847096
    169 rdf:type schema:CreativeWork
    170 https://doi.org/10.1073/pnas.91.18.8348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041581209
    171 rdf:type schema:CreativeWork
    172 https://doi.org/10.1101/gad.1.10.1183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017967255
    173 rdf:type schema:CreativeWork
    174 https://doi.org/10.1111/j.1399-302x.1989.tb00243.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027740434
    175 rdf:type schema:CreativeWork
    176 https://doi.org/10.1126/science.227.4691.1229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062529900
    177 rdf:type schema:CreativeWork
    178 https://doi.org/10.1126/science.236.4806.1259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062534237
    179 rdf:type schema:CreativeWork
    180 https://doi.org/10.1126/science.244.4901.174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062537666
    181 rdf:type schema:CreativeWork
    182 https://doi.org/10.1126/science.250.4983.959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062541055
    183 rdf:type schema:CreativeWork
    184 https://doi.org/10.1126/science.2531466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062542740
    185 rdf:type schema:CreativeWork
    186 https://doi.org/10.1126/science.2928780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062574307
    187 rdf:type schema:CreativeWork
    188 https://doi.org/10.1126/science.7732380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649108
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1146/annurev.mi.35.100181.002401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008198329
    191 rdf:type schema:CreativeWork
    192 https://www.grid.ac/institutes/grid.423136.1 schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...