2001-09-18T00:00
AUTHORSMARKOWITZ SANFORD D , BRATTAIN MICHAEL G , WILLSON JAMES K V
ABSTRACTThis invention is based on the discovery that the type II TGFβ receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis. More... »
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