Replication-defective adenovirus human type 5 recombinant as a vaccine carrier


Ontology type: sgo:Patent     


Patent Info

DATE

2001-09-11T00:00

AUTHORS

Hildegund C. J. Ertl , James M. Wilson

ABSTRACT

A replication defective recombinant adenovirus is provided which contains a complete deletion of its E1 gene and at least a partial deletion of its E3 gene, said virus containing in the site of the E1 deletion a sequence comprising a non-adenovirus promoter directing the replication and expression of DNA encoding a heterologous protein from a disease-causing agent, which, when administered to a mammal in said recombinant virus, elicits a substantially complete protective immune response against the agent. Pharmaceutical and veterinary products containing the recombinant adenovirus are provided. More... »

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