Insulin derivatives having a rapid onset of action


Ontology type: sgo:Patent     


Patent Info

DATE

2001-04-24T00:00

AUTHORS

Johann Ertl , Paul Habermann , Karl Geisen , Gerhard Seipke

ABSTRACT

The present invention relates to insulin derivatives which in comparison to human insulin, have an accelerated onset of action, to a process for their preparation and to their use, in particular in pharmaceutical preparations for the treatment of diabetes mellitus. In particular, the present invention relates to insulin derivatives or physiologically tolerable salts thereof in which asparagine (Asn) in position B3 of the B chain is replaced by a naturally occurring basic amino acid residue and at least one amino acid residue in the positions B27, B28 or B29 of the B chain is replaced by another naturally occurring amino acid residue, it optionally being possible for asparagine (Asn) in position 21 of the A chain to be replaced by Asp, Gly, Ser, Thr or Ala and for phenylalanine (Phe) in position B1 of the B chain and the amino acid residue in position B30 of the B chain to be absent. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3053", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Johann Ertl", 
        "type": "Person"
      }, 
      {
        "name": "Paul Habermann", 
        "type": "Person"
      }, 
      {
        "name": "Karl Geisen", 
        "type": "Person"
      }, 
      {
        "name": "Gerhard Seipke", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/188721a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009916757", 
          "https://doi.org/10.1038/188721a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi972071p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055214691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi972071p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055214691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.14.11.942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070745314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.bmb.a072309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078901743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.bmb.a072307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078947915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.bmb.a072323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079210461"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-04-24T00:00", 
    "description": "

The present invention relates to insulin derivatives which in comparison to human insulin, have an accelerated onset of action, to a process for their preparation and to their use, in particular in pharmaceutical preparations for the treatment of diabetes mellitus. In particular, the present invention relates to insulin derivatives or physiologically tolerable salts thereof in which asparagine (Asn) in position B3 of the B chain is replaced by a naturally occurring basic amino acid residue and at least one amino acid residue in the positions B27, B28 or B29 of the B chain is replaced by another naturally occurring amino acid residue, it optionally being possible for asparagine (Asn) in position 21 of the A chain to be replaced by Asp, Gly, Ser, Thr or Ala and for phenylalanine (Phe) in position B1 of the B chain and the amino acid residue in position B30 of the B chain to be absent.

", "id": "sg:patent.US-6221633-B1", "keywords": [ "derivative", "rapid onset", "invention", "comparison", "human insulin", "onset", "preparation", "Pharmaceutical Preparation", "diabetes mellitus", "salt", "asparagine", "Asn", "B3", "B-chain", "amino acid residue", "B27", "chain", "Viperidae", "Ser", "Thr", "phenylalanine", "Phe", "B1" ], "name": "Insulin derivatives having a rapid onset of action", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.417555.7", "type": "Organization" }, { "id": "https://www.grid.ac/institutes/grid.420214.1", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-6221633-B1" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:27", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_03088.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-6221633-B1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-6221633-B1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-6221633-B1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-6221633-B1'


 

This table displays all metadata directly associated to this object as RDF triples.

78 TRIPLES      15 PREDICATES      44 URIs      31 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-6221633-B1 schema:about anzsrc-for:3053
2 schema:author N85d733890a204b1db9a2b33e02336cdf
3 schema:citation sg:pub.10.1038/188721a0
4 https://doi.org/10.1021/bi972071p
5 https://doi.org/10.1093/oxfordjournals.bmb.a072307
6 https://doi.org/10.1093/oxfordjournals.bmb.a072309
7 https://doi.org/10.1093/oxfordjournals.bmb.a072323
8 https://doi.org/10.2337/diacare.14.11.942
9 schema:datePublished 2001-04-24T00:00
10 schema:description <p>The present invention relates to insulin derivatives which in comparison to human insulin, have an accelerated onset of action, to a process for their preparation and to their use, in particular in pharmaceutical preparations for the treatment of diabetes mellitus. In particular, the present invention relates to insulin derivatives or physiologically tolerable salts thereof in which asparagine (Asn) in position B3 of the B chain is replaced by a naturally occurring basic amino acid residue and at least one amino acid residue in the positions B27, B28 or B29 of the B chain is replaced by another naturally occurring amino acid residue, it optionally being possible for asparagine (Asn) in position 21 of the A chain to be replaced by Asp, Gly, Ser, Thr or Ala and for phenylalanine (Phe) in position B1 of the B chain and the amino acid residue in position B30 of the B chain to be absent.</p>
11 schema:keywords Asn
12 B-chain
13 B1
14 B27
15 B3
16 Pharmaceutical Preparation
17 Phe
18 Ser
19 Thr
20 Viperidae
21 amino acid residue
22 asparagine
23 chain
24 comparison
25 derivative
26 diabetes mellitus
27 human insulin
28 invention
29 onset
30 phenylalanine
31 preparation
32 rapid onset
33 salt
34 schema:name Insulin derivatives having a rapid onset of action
35 schema:recipient https://www.grid.ac/institutes/grid.417555.7
36 https://www.grid.ac/institutes/grid.420214.1
37 schema:sameAs https://app.dimensions.ai/details/patent/US-6221633-B1
38 schema:sdDatePublished 2019-04-18T10:27
39 schema:sdLicense https://scigraph.springernature.com/explorer/license/
40 schema:sdPublisher N704ac6fb61d44800b009964d90104d53
41 sgo:license sg:explorer/license/
42 sgo:sdDataset patents
43 rdf:type sgo:Patent
44 N392a6981cd634e488e70ca0b7597b1e4 schema:name Johann Ertl
45 rdf:type schema:Person
46 N52c33db010f3444bb97f82c104887cbd rdf:first N6291271809ba44d4a056e9bc000b8404
47 rdf:rest Nb8697a980f4d41869f390c0306796988
48 N5ccf59c909ff49589ec99086e1535b0e rdf:first N6a61f09574ec457a8e4437e4d51a6106
49 rdf:rest N52c33db010f3444bb97f82c104887cbd
50 N6291271809ba44d4a056e9bc000b8404 schema:name Karl Geisen
51 rdf:type schema:Person
52 N6a61f09574ec457a8e4437e4d51a6106 schema:name Paul Habermann
53 rdf:type schema:Person
54 N704ac6fb61d44800b009964d90104d53 schema:name Springer Nature - SN SciGraph project
55 rdf:type schema:Organization
56 N7268044b27c141b0ac6ecbe928ff4e22 schema:name Gerhard Seipke
57 rdf:type schema:Person
58 N85d733890a204b1db9a2b33e02336cdf rdf:first N392a6981cd634e488e70ca0b7597b1e4
59 rdf:rest N5ccf59c909ff49589ec99086e1535b0e
60 Nb8697a980f4d41869f390c0306796988 rdf:first N7268044b27c141b0ac6ecbe928ff4e22
61 rdf:rest rdf:nil
62 anzsrc-for:3053 schema:inDefinedTermSet anzsrc-for:
63 rdf:type schema:DefinedTerm
64 sg:pub.10.1038/188721a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009916757
65 https://doi.org/10.1038/188721a0
66 rdf:type schema:CreativeWork
67 https://doi.org/10.1021/bi972071p schema:sameAs https://app.dimensions.ai/details/publication/pub.1055214691
68 rdf:type schema:CreativeWork
69 https://doi.org/10.1093/oxfordjournals.bmb.a072307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078947915
70 rdf:type schema:CreativeWork
71 https://doi.org/10.1093/oxfordjournals.bmb.a072309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078901743
72 rdf:type schema:CreativeWork
73 https://doi.org/10.1093/oxfordjournals.bmb.a072323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079210461
74 rdf:type schema:CreativeWork
75 https://doi.org/10.2337/diacare.14.11.942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070745314
76 rdf:type schema:CreativeWork
77 https://www.grid.ac/institutes/grid.417555.7 schema:Organization
78 https://www.grid.ac/institutes/grid.420214.1 schema:Organization
 




Preview window. Press ESC to close (or click here)


...