Adenovirus and method of use thereof


Ontology type: sgo:Patent     


Patent Info

DATE

2001-03-20T00:00

AUTHORS

James M. Wilson , Krishna J. Fisher , Shu-Jen Chen , Matthew Weitzman

ABSTRACT

A recombinant adenovirus and a method for producing the virus are provided which utilize a recombinant shuttle vector comprising adenovirus DNA sequence for the 5′ and 3′ cis-elements necessary for replication and virion encapsidation in the absence of sequence encoding viral genes and a selected minigene linked thereto, and a helper adenovirus comprising sufficient adenovirus gene sequences necessary for a productive viral infection. Desirably the helper gene is crippled by modifications to its 5′ packaging sequences, which facilitates purification of the viral particle from the helper virus. More... »

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