Nucleotide Sequence Coding Enzymatic Polypeptide Associated With Modulation Of Signal Transduction Enzymes; For The Treatment Of Cell Proliferative Defects And ...


Ontology type: sgo:Patent     


Patent Info

DATE

2000-10-24T00:00

AUTHORS

DAVIS ROGER J , WHITMARSH ALAN , TOURNIER CATHY

ABSTRACT

Disclosed are human mitogen-activated (MAP) kinase kinase isoforms (MKKs). MKKs mediate unique signal transduction pathways that activate human MAP kinases p38 and JNK, which result in activation of other factors, including activating transcription factor-2 (ATF2) and c-Jun. The pathways are activated by a number of factors, including cytokines and environmental stress. Methods are provided for identifying reagents that modulate MKK function or activity and for the use of such reagents in the treatment of MKK-mediated disorders. More... »

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