Modulating inflammation with cytochrome P-450 activators and inhibitors


Ontology type: sgo:Patent     


Patent Info

DATE

2000-09-19T00:00

AUTHORS

Wieslaw Kozak , Matthew J. Kluger , Yohannes Tesfaigzi

ABSTRACT

This invention relates to methods of modulating inflammation in mammals. Inflammation is modulated by regulating the cytochrome P-450 pathway. Inflammation is reduced by treating the subject with substances, such as bezafibrate and clofibrate, which induce the P-450 pathway. Inflammation is promoted by treating the subject with substances, such as proadifen, econazole, and clotrimazole, which inhibit the cytochrome P-450 pathway. More... »

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