MTS1 gene


Ontology type: sgo:Patent     


Patent Info

DATE

2000-07-18T00:00

AUTHORS

Alexander Kamb

ABSTRACT

The present invention relates to somatic mutations in the Multiple Tumor Suppressor (MTS) gene in human cancers and their use in the diagnosis and prognosis of human cancer. The invention further relates to germ line mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3142", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Alexander Kamb", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/366707a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000182688", 
          "https://doi.org/10.1038/366707a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.3.7.1086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002444082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.19.9146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009445669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1994.1491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009692223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/350512a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014976902", 
          "https://doi.org/10.1038/350512a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/366704a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015821919", 
          "https://doi.org/10.1038/366704a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/366701a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020218634", 
          "https://doi.org/10.1038/366701a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008390-199212000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021281765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008390-199212000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021281765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.21.10557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028417988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90360-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028885121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.2.709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029903810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90499-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034836400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0994-22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042277853", 
          "https://doi.org/10.1038/ng0994-22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/366634a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044157091", 
          "https://doi.org/10.1038/366634a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/371257a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045553304", 
          "https://doi.org/10.1038/371257a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/368753a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045854758", 
          "https://doi.org/10.1038/368753a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.16.7563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052984242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1439824", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062482274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8153634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062652972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1995.tb07026.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082539378"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-07-18T00:00", 
    "description": "

The present invention relates to somatic mutations in the Multiple Tumor Suppressor (MTS) gene in human cancers and their use in the diagnosis and prognosis of human cancer. The invention further relates to germ line mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.

", "id": "sg:patent.US-6090578-A", "keywords": [ "p16 gene", "invention", "somatic mutation", "tumor suppressor", "gene", "human cancer", "diagnosis", "prognosis", "Germ-Line Mutation", "tumor suppressor gene", "predisposition", "melanoma", "leukemia", "Astrocytoma", "Glioblastoma", "lymphoma", "glioma", "Hodgkin's", "CLL", "Neoplasm", "pancreas", "breast", "Thyroid Gland", "ovary", "uterus", "testis", "kidney", "stomach", "rectum", "therapy", "mutation", "Genetic Therapy", "replacement therapy", "protein", "Mass Screening", "drug", "cancer therapy" ], "name": "MTS1 gene", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.420032.7", "type": "Organization" }, { "id": "https://www.grid.ac/institutes/grid.223827.e", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-6090578-A" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:27", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_03077.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-6090578-A'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-6090578-A'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-6090578-A'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-6090578-A'


 

This table displays all metadata directly associated to this object as RDF triples.

129 TRIPLES      15 PREDICATES      72 URIs      45 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-6090578-A schema:about anzsrc-for:3142
2 schema:author N9c4b9bcfa07c49bf98f1c2dda331c243
3 schema:citation sg:pub.10.1038/350512a0
4 sg:pub.10.1038/366634a0
5 sg:pub.10.1038/366701a0
6 sg:pub.10.1038/366704a0
7 sg:pub.10.1038/366707a0
8 sg:pub.10.1038/368753a0
9 sg:pub.10.1038/371257a0
10 sg:pub.10.1038/ng0994-22
11 https://doi.org/10.1002/j.1460-2075.1995.tb07026.x
12 https://doi.org/10.1006/geno.1994.1491
13 https://doi.org/10.1016/0092-8674(92)90360-o
14 https://doi.org/10.1016/0092-8674(93)90499-g
15 https://doi.org/10.1073/pnas.89.19.9146
16 https://doi.org/10.1073/pnas.89.21.10557
17 https://doi.org/10.1073/pnas.91.16.7563
18 https://doi.org/10.1073/pnas.91.2.709
19 https://doi.org/10.1097/00008390-199212000-00007
20 https://doi.org/10.1101/gad.3.7.1086
21 https://doi.org/10.1126/science.1439824
22 https://doi.org/10.1126/science.8153634
23 schema:datePublished 2000-07-18T00:00
24 schema:description <p>The present invention relates to somatic mutations in the Multiple Tumor Suppressor (MTS) gene in human cancers and their use in the diagnosis and prognosis of human cancer. The invention further relates to germ line mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.</p>
25 schema:keywords Astrocytoma
26 CLL
27 Genetic Therapy
28 Germ-Line Mutation
29 Glioblastoma
30 Hodgkin's
31 Mass Screening
32 Neoplasm
33 Thyroid Gland
34 breast
35 cancer therapy
36 diagnosis
37 drug
38 gene
39 glioma
40 human cancer
41 invention
42 kidney
43 leukemia
44 lymphoma
45 melanoma
46 mutation
47 ovary
48 p16 gene
49 pancreas
50 predisposition
51 prognosis
52 protein
53 rectum
54 replacement therapy
55 somatic mutation
56 stomach
57 testis
58 therapy
59 tumor suppressor
60 tumor suppressor gene
61 uterus
62 schema:name MTS1 gene
63 schema:recipient https://www.grid.ac/institutes/grid.223827.e
64 https://www.grid.ac/institutes/grid.420032.7
65 schema:sameAs https://app.dimensions.ai/details/patent/US-6090578-A
66 schema:sdDatePublished 2019-04-18T10:27
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher N5f29cf7f5d844f8eb3be5134c42010dd
69 sgo:license sg:explorer/license/
70 sgo:sdDataset patents
71 rdf:type sgo:Patent
72 N5f29cf7f5d844f8eb3be5134c42010dd schema:name Springer Nature - SN SciGraph project
73 rdf:type schema:Organization
74 N9c4b9bcfa07c49bf98f1c2dda331c243 rdf:first N9fe2ec4826c64de5af2bce8e6493bc68
75 rdf:rest rdf:nil
76 N9fe2ec4826c64de5af2bce8e6493bc68 schema:name Alexander Kamb
77 rdf:type schema:Person
78 anzsrc-for:3142 schema:inDefinedTermSet anzsrc-for:
79 rdf:type schema:DefinedTerm
80 sg:pub.10.1038/350512a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014976902
81 https://doi.org/10.1038/350512a0
82 rdf:type schema:CreativeWork
83 sg:pub.10.1038/366634a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044157091
84 https://doi.org/10.1038/366634a0
85 rdf:type schema:CreativeWork
86 sg:pub.10.1038/366701a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020218634
87 https://doi.org/10.1038/366701a0
88 rdf:type schema:CreativeWork
89 sg:pub.10.1038/366704a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015821919
90 https://doi.org/10.1038/366704a0
91 rdf:type schema:CreativeWork
92 sg:pub.10.1038/366707a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000182688
93 https://doi.org/10.1038/366707a0
94 rdf:type schema:CreativeWork
95 sg:pub.10.1038/368753a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045854758
96 https://doi.org/10.1038/368753a0
97 rdf:type schema:CreativeWork
98 sg:pub.10.1038/371257a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045553304
99 https://doi.org/10.1038/371257a0
100 rdf:type schema:CreativeWork
101 sg:pub.10.1038/ng0994-22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042277853
102 https://doi.org/10.1038/ng0994-22
103 rdf:type schema:CreativeWork
104 https://doi.org/10.1002/j.1460-2075.1995.tb07026.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082539378
105 rdf:type schema:CreativeWork
106 https://doi.org/10.1006/geno.1994.1491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009692223
107 rdf:type schema:CreativeWork
108 https://doi.org/10.1016/0092-8674(92)90360-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1028885121
109 rdf:type schema:CreativeWork
110 https://doi.org/10.1016/0092-8674(93)90499-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1034836400
111 rdf:type schema:CreativeWork
112 https://doi.org/10.1073/pnas.89.19.9146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009445669
113 rdf:type schema:CreativeWork
114 https://doi.org/10.1073/pnas.89.21.10557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028417988
115 rdf:type schema:CreativeWork
116 https://doi.org/10.1073/pnas.91.16.7563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052984242
117 rdf:type schema:CreativeWork
118 https://doi.org/10.1073/pnas.91.2.709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029903810
119 rdf:type schema:CreativeWork
120 https://doi.org/10.1097/00008390-199212000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021281765
121 rdf:type schema:CreativeWork
122 https://doi.org/10.1101/gad.3.7.1086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002444082
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1126/science.1439824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062482274
125 rdf:type schema:CreativeWork
126 https://doi.org/10.1126/science.8153634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652972
127 rdf:type schema:CreativeWork
128 https://www.grid.ac/institutes/grid.223827.e schema:Organization
129 https://www.grid.ac/institutes/grid.420032.7 schema:Organization
 




Preview window. Press ESC to close (or click here)


...