Chimeric receptors for the generation of selectively-activatable TH-independent cytotoxic T cells


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Andrew Lawrence Feldhaus , Lori Ann Jones

ABSTRACT

The invention provides cytotoxic T lymphocytes that express a chimeric cell surface receptor. The chimeric receptor enables the lymphocytes to become activated and to proliferate (via a TH -independent autocrine cycle) in response to adhesion between the lymphocyte and an antigen displaying cell (ADC) that might not normally activate the T cell. The chimeric receptors of the present invention comprise fusion polypeptides of the following structure:XC--TM--IC28wherein (XC) is an extracellular region derived from a receptor for a ligand that is expressed on the surface of an antigen-displaying cell, fused via a transmembrane region is (TM) to an intracellular region (IC28) which is derived from the intracellular region of the CD28 receptor. More... »

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The invention provides cytotoxic T lymphocytes that express a chimeric cell surface receptor. The chimeric receptor enables the lymphocytes to become activated and to proliferate (via a TH -independent autocrine cycle) in response to adhesion between the lymphocyte and an antigen displaying cell (ADC) that might not normally activate the T cell. The chimeric receptors of the present invention comprise fusion polypeptides of the following structure:

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wherein (XC) is an extracellular region derived from a receptor for a ligand that is expressed on the surface of an antigen-displaying cell, fused via a transmembrane region is (TM) to an intracellular region (IC28) which is derived from the intracellular region of the CD28 receptor.

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