Oligonucleotides From Mutated Dna Sequences Coding For Mitogen-Activated Protein Kinase; For Diagnosis Of Breast, Pancreatic, Colorectal And Testicular Cancers; For ...


Ontology type: sgo:Patent     


Patent Info

DATE

1999-11-23T00:00

AUTHORS

TENG DAVID H-F , TAVTIGIAN SEAN V , PERRY III WILLIAM L , SKOLNICK MARK H

ABSTRACT

The present invention relates to mutations in the MKK4 gene in human cancers and their use in the diagnosis and prognosis of human cancer. Specific mutations in the MKK4 gene which are associated with breast, pancreatic, colorectal and testicular cancers have been identified. The invention also relates to the therapy of human cancers which have a mutation in the MKK4 gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy. More... »

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