Cell-cycle regulatory proteins, and uses related thereto


Ontology type: sgo:Patent     


Patent Info

DATE

1999-10-19T00:00

AUTHORS

David H. Beach , Douglas J. Demetrick , Manuel Serrano , Gregory J. Hannon

ABSTRACT

The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of a novel family of cell-cycle regulatory proteins ("CCR-proteins"). As described herein, this family of proteins includes a polypeptide having an apparent molecular weight of 16 kDa, and a polypeptide having an apparent molecular weight of approximately 15 kDa, each of which can function as an inhibitor of cell-cycle progression, and therefore ultimately of cell growth. Thus, similar to the role of p21 to the p53 checkpoint, the subject CCR-proteins may function coordinately with the cell-cycle regulatory protein, retinoblastoma (RB). Furthermore, the CCR-protein family includes a protein having an apparent molecular weight of 13.5 kDa (hereinafter "p13.5"). The presumptive role of p13.5, like p16 and p15, is in the regulation of the cell-cycle. More... »

Related SciGraph Publications

  • 1995-10. Radiation-induced cell cycle arrest compromised by p21 deficiency in NATURE
  • 1991-04. A novel cyclin encoded by a bcl1-linked candidate oncogene in NATURE
  • 1994-07. P16 gene in uncultured tumours in NATURE
  • 1988-09. Finding the anti-oncogene. in SCIENTIFIC AMERICAN
  • 1989-07. A novel genetic system to detect protein–protein interactions in NATURE
  • 1994-09. Familial melanoma and p16 — a hung jury in NATURE GENETICS
  • 1994-09. pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest in NATURE
  • 1994-09. Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus in NATURE GENETICS
  • 1993-12. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 in NATURE
  • 1988-09. Multiple phosphorylated forms of the product of the fission yeast cell division cycle gene cdc2+ in CURRENT GENETICS
  • 1994-04. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers in NATURE
  • 1993-12. p21 is a universal inhibitor of cyclin kinases in NATURE
  • 1983-10. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma in NATURE
  • 1994-09. Germline p16 mutations in familial melanoma in NATURE GENETICS
  • 1994-09. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma in NATURE GENETICS
  • 1990-02. Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma in NATURE
  • 1985-04. Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus in NATURE
  • 1990-08. Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B in NATURE
  • 1993-06. Crystal structure of cyclin-dependent kinase 2 in NATURE
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2581", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "David H. Beach", 
            "type": "Person"
          }, 
          {
            "name": "Douglas J. Demetrick", 
            "type": "Person"
          }, 
          {
            "name": "Manuel Serrano", 
            "type": "Person"
          }, 
          {
            "name": "Gregory J. Hannon", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1101/gad.7.3.331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000187410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00376743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003082112", 
              "https://doi.org/10.1007/bf00376743"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00376743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003082112", 
              "https://doi.org/10.1007/bf00376743"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0888-7543(92)90127-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003171281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0958-1669(92)90084-v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004165446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.15.5.2682", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005110459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90723-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006212321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1996.0045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006246307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.119.5.1017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006628324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1994.2294", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007505285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0304-419x(90)90013-q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008481184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0304-419x(90)90013-q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008481184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/370183a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009320671", 
              "https://doi.org/10.1038/370183a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(92)90518-h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009706637"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90636-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009780866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(91)90101-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011021705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.13.8.5122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011616001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90136-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011690149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.14.3.2077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013411441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/350512a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014976902", 
              "https://doi.org/10.1038/350512a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90573-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015252677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.7.8.1559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015564012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/366704a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015821919", 
              "https://doi.org/10.1038/366704a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.23.11045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016446367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(95)90271-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020126871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/366701a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020218634", 
              "https://doi.org/10.1038/366701a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/343555a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022183391", 
              "https://doi.org/10.1038/343555a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0994-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023732127", 
              "https://doi.org/10.1038/ng0994-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/363595a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024374199", 
              "https://doi.org/10.1038/363595a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.121.6.1397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024506408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/340245a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028860985", 
              "https://doi.org/10.1038/340245a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/340245a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028860985", 
              "https://doi.org/10.1038/340245a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(92)90360-o", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028885121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0994-15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029407853", 
              "https://doi.org/10.1038/ng0994-15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1994.2090", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030646059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.4.9.897", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033410916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(91)90100-d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034276940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90499-g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034836400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.12.5291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035378612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0168-1656(94)90062-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037214734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0168-1656(94)90062-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037214734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.111.5.2129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037648739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/314633a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038317228", 
              "https://doi.org/10.1038/314633a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.8.24.2939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038530556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90188-k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039577503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.cb.06.110190.003121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041319269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(89)90975-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041796656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0994-22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042277853", 
              "https://doi.org/10.1038/ng0994-22"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/346760a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042858506", 
              "https://doi.org/10.1038/346760a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/371257a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045553304", 
              "https://doi.org/10.1038/371257a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/368753a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045854758", 
              "https://doi.org/10.1038/368753a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0994-27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046920232", 
              "https://doi.org/10.1038/ng0994-27"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm198605083141901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047504105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.84.24.9059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048059921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.83.8.2438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048089140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.8.3.1247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048134605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0168-9525(88)90134-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049347128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0168-9525(88)90134-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049347128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(89)90949-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049470439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/305779a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049589192", 
              "https://doi.org/10.1038/305779a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.106.3.761", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049975817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/377552a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050160413", 
              "https://doi.org/10.1038/377552a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(89)90429-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050439710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0955-0674(94)90142-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050629018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(91)90042-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051296798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0888-7543(92)90126-d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052508633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.8.1.9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052772922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90251-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054549979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/scientificamerican0988-44", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056600892", 
              "https://doi.org/10.1038/scientificamerican0988-44"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/dna.1994.13.343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059251346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/protein/7.2.243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059981017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1439824", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062482274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1659741", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062497985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7652577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062648309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7667636", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062648356"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7809631", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062649804"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7939631", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062650650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8023167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062652014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8073268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062652144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8153613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062652951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8153634", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062652972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8475385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062655746"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1999-10-19T00:00", 
        "description": "

    The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of a novel family of cell-cycle regulatory proteins (\"CCR-proteins\"). As described herein, this family of proteins includes a polypeptide having an apparent molecular weight of 16 kDa, and a polypeptide having an apparent molecular weight of approximately 15 kDa, each of which can function as an inhibitor of cell-cycle progression, and therefore ultimately of cell growth. Thus, similar to the role of p21 to the p53 checkpoint, the subject CCR-proteins may function coordinately with the cell-cycle regulatory protein, retinoblastoma (RB). Furthermore, the CCR-protein family includes a protein having an apparent molecular weight of 13.5 kDa (hereinafter \"p13.5\"). The presumptive role of p13.5, like p16 and p15, is in the regulation of the cell-cycle.

    ", "id": "sg:patent.US-5968821-A", "keywords": [ "cell cycle regulatory protein", "invention", "discovery", "eukaryotic cell", "mammalian cell", "novel family", "protein", "family", "polypeptide", "apparent molecular weight", "kDa", "inhibitor", "cell cycle progression", "cell growth", "p21", "checkpoint", "Rb", "protein family", "p16", "p15", "Formal Social Control" ], "name": "Cell-cycle regulatory proteins, and uses related thereto", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.225279.9", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-5968821-A" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:27", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_03064.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-5968821-A'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-5968821-A'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-5968821-A'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-5968821-A'


     

    This table displays all metadata directly associated to this object as RDF triples.

    305 TRIPLES      15 PREDICATES      112 URIs      29 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-5968821-A schema:about anzsrc-for:2581
    2 schema:author N186f81e5f93d4f86a83fe35aa4bfdee6
    3 schema:citation sg:pub.10.1007/bf00376743
    4 sg:pub.10.1038/305779a0
    5 sg:pub.10.1038/314633a0
    6 sg:pub.10.1038/340245a0
    7 sg:pub.10.1038/343555a0
    8 sg:pub.10.1038/346760a0
    9 sg:pub.10.1038/350512a0
    10 sg:pub.10.1038/363595a0
    11 sg:pub.10.1038/366701a0
    12 sg:pub.10.1038/366704a0
    13 sg:pub.10.1038/368753a0
    14 sg:pub.10.1038/370183a0
    15 sg:pub.10.1038/371257a0
    16 sg:pub.10.1038/377552a0
    17 sg:pub.10.1038/ng0994-15
    18 sg:pub.10.1038/ng0994-22
    19 sg:pub.10.1038/ng0994-27
    20 sg:pub.10.1038/ng0994-3
    21 sg:pub.10.1038/scientificamerican0988-44
    22 https://doi.org/10.1006/bbrc.1994.2090
    23 https://doi.org/10.1006/bbrc.1994.2294
    24 https://doi.org/10.1006/bbrc.1996.0045
    25 https://doi.org/10.1016/0092-8674(89)90429-7
    26 https://doi.org/10.1016/0092-8674(89)90949-5
    27 https://doi.org/10.1016/0092-8674(89)90975-6
    28 https://doi.org/10.1016/0092-8674(90)90188-k
    29 https://doi.org/10.1016/0092-8674(90)90251-9
    30 https://doi.org/10.1016/0092-8674(91)90042-w
    31 https://doi.org/10.1016/0092-8674(91)90100-d
    32 https://doi.org/10.1016/0092-8674(91)90101-4
    33 https://doi.org/10.1016/0092-8674(92)90360-o
    34 https://doi.org/10.1016/0092-8674(92)90518-h
    35 https://doi.org/10.1016/0092-8674(93)90136-e
    36 https://doi.org/10.1016/0092-8674(93)90499-g
    37 https://doi.org/10.1016/0092-8674(93)90636-5
    38 https://doi.org/10.1016/0092-8674(93)90723-4
    39 https://doi.org/10.1016/0092-8674(94)90573-8
    40 https://doi.org/10.1016/0092-8674(95)90271-6
    41 https://doi.org/10.1016/0168-1656(94)90062-0
    42 https://doi.org/10.1016/0168-9525(88)90134-5
    43 https://doi.org/10.1016/0304-419x(90)90013-q
    44 https://doi.org/10.1016/0888-7543(92)90126-d
    45 https://doi.org/10.1016/0888-7543(92)90127-e
    46 https://doi.org/10.1016/0955-0674(94)90142-2
    47 https://doi.org/10.1016/0958-1669(92)90084-v
    48 https://doi.org/10.1056/nejm198605083141901
    49 https://doi.org/10.1073/pnas.83.8.2438
    50 https://doi.org/10.1073/pnas.84.24.9059
    51 https://doi.org/10.1073/pnas.91.12.5291
    52 https://doi.org/10.1073/pnas.91.23.11045
    53 https://doi.org/10.1083/jcb.106.3.761
    54 https://doi.org/10.1083/jcb.111.5.2129
    55 https://doi.org/10.1083/jcb.119.5.1017
    56 https://doi.org/10.1083/jcb.121.6.1397
    57 https://doi.org/10.1089/dna.1994.13.343
    58 https://doi.org/10.1091/mbc.4.9.897
    59 https://doi.org/10.1093/protein/7.2.243
    60 https://doi.org/10.1101/gad.7.3.331
    61 https://doi.org/10.1101/gad.7.8.1559
    62 https://doi.org/10.1101/gad.8.1.9
    63 https://doi.org/10.1101/gad.8.24.2939
    64 https://doi.org/10.1126/science.1439824
    65 https://doi.org/10.1126/science.1659741
    66 https://doi.org/10.1126/science.7652577
    67 https://doi.org/10.1126/science.7667636
    68 https://doi.org/10.1126/science.7809631
    69 https://doi.org/10.1126/science.7939631
    70 https://doi.org/10.1126/science.8023167
    71 https://doi.org/10.1126/science.8073268
    72 https://doi.org/10.1126/science.8153613
    73 https://doi.org/10.1126/science.8153634
    74 https://doi.org/10.1126/science.8475385
    75 https://doi.org/10.1128/mcb.13.8.5122
    76 https://doi.org/10.1128/mcb.14.3.2077
    77 https://doi.org/10.1128/mcb.15.5.2682
    78 https://doi.org/10.1128/mcb.8.3.1247
    79 https://doi.org/10.1146/annurev.cb.06.110190.003121
    80 schema:datePublished 1999-10-19T00:00
    81 schema:description <p>The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of a novel family of cell-cycle regulatory proteins ("CCR-proteins"). As described herein, this family of proteins includes a polypeptide having an apparent molecular weight of 16 kDa, and a polypeptide having an apparent molecular weight of approximately 15 kDa, each of which can function as an inhibitor of cell-cycle progression, and therefore ultimately of cell growth. Thus, similar to the role of p21 to the p53 checkpoint, the subject CCR-proteins may function coordinately with the cell-cycle regulatory protein, retinoblastoma (RB). Furthermore, the CCR-protein family includes a protein having an apparent molecular weight of 13.5 kDa (hereinafter "p13.5"). The presumptive role of p13.5, like p16 and p15, is in the regulation of the cell-cycle.</p>
    82 schema:keywords Formal Social Control
    83 Rb
    84 apparent molecular weight
    85 cell cycle progression
    86 cell cycle regulatory protein
    87 cell growth
    88 checkpoint
    89 discovery
    90 eukaryotic cell
    91 family
    92 inhibitor
    93 invention
    94 kDa
    95 mammalian cell
    96 novel family
    97 p15
    98 p16
    99 p21
    100 polypeptide
    101 protein
    102 protein family
    103 schema:name Cell-cycle regulatory proteins, and uses related thereto
    104 schema:recipient https://www.grid.ac/institutes/grid.225279.9
    105 schema:sameAs https://app.dimensions.ai/details/patent/US-5968821-A
    106 schema:sdDatePublished 2019-04-18T10:27
    107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    108 schema:sdPublisher N1f839e2b0b3a4b76856dbacd8cb8970f
    109 sgo:license sg:explorer/license/
    110 sgo:sdDataset patents
    111 rdf:type sgo:Patent
    112 N00b5e1fe4ca9458286df307e5fc3f8f6 rdf:first N765561a83e604eeda5ac7ece0ad4e5c5
    113 rdf:rest N8a51e609e8444b46baca8d776e652e97
    114 N186f81e5f93d4f86a83fe35aa4bfdee6 rdf:first N63a29e7092194504806bda5ec215992d
    115 rdf:rest N00b5e1fe4ca9458286df307e5fc3f8f6
    116 N1f839e2b0b3a4b76856dbacd8cb8970f schema:name Springer Nature - SN SciGraph project
    117 rdf:type schema:Organization
    118 N468a7b90e4404f298210002bb4a6992b schema:name Manuel Serrano
    119 rdf:type schema:Person
    120 N63a29e7092194504806bda5ec215992d schema:name David H. Beach
    121 rdf:type schema:Person
    122 N765561a83e604eeda5ac7ece0ad4e5c5 schema:name Douglas J. Demetrick
    123 rdf:type schema:Person
    124 N8086019f39734965b6de2c5e379a1dfa rdf:first N92e87ce6ab25417cb4b47f0a6c05a20a
    125 rdf:rest rdf:nil
    126 N8a51e609e8444b46baca8d776e652e97 rdf:first N468a7b90e4404f298210002bb4a6992b
    127 rdf:rest N8086019f39734965b6de2c5e379a1dfa
    128 N92e87ce6ab25417cb4b47f0a6c05a20a schema:name Gregory J. Hannon
    129 rdf:type schema:Person
    130 anzsrc-for:2581 schema:inDefinedTermSet anzsrc-for:
    131 rdf:type schema:DefinedTerm
    132 sg:pub.10.1007/bf00376743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003082112
    133 https://doi.org/10.1007/bf00376743
    134 rdf:type schema:CreativeWork
    135 sg:pub.10.1038/305779a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049589192
    136 https://doi.org/10.1038/305779a0
    137 rdf:type schema:CreativeWork
    138 sg:pub.10.1038/314633a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038317228
    139 https://doi.org/10.1038/314633a0
    140 rdf:type schema:CreativeWork
    141 sg:pub.10.1038/340245a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028860985
    142 https://doi.org/10.1038/340245a0
    143 rdf:type schema:CreativeWork
    144 sg:pub.10.1038/343555a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022183391
    145 https://doi.org/10.1038/343555a0
    146 rdf:type schema:CreativeWork
    147 sg:pub.10.1038/346760a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042858506
    148 https://doi.org/10.1038/346760a0
    149 rdf:type schema:CreativeWork
    150 sg:pub.10.1038/350512a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014976902
    151 https://doi.org/10.1038/350512a0
    152 rdf:type schema:CreativeWork
    153 sg:pub.10.1038/363595a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024374199
    154 https://doi.org/10.1038/363595a0
    155 rdf:type schema:CreativeWork
    156 sg:pub.10.1038/366701a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020218634
    157 https://doi.org/10.1038/366701a0
    158 rdf:type schema:CreativeWork
    159 sg:pub.10.1038/366704a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015821919
    160 https://doi.org/10.1038/366704a0
    161 rdf:type schema:CreativeWork
    162 sg:pub.10.1038/368753a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045854758
    163 https://doi.org/10.1038/368753a0
    164 rdf:type schema:CreativeWork
    165 sg:pub.10.1038/370183a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009320671
    166 https://doi.org/10.1038/370183a0
    167 rdf:type schema:CreativeWork
    168 sg:pub.10.1038/371257a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045553304
    169 https://doi.org/10.1038/371257a0
    170 rdf:type schema:CreativeWork
    171 sg:pub.10.1038/377552a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050160413
    172 https://doi.org/10.1038/377552a0
    173 rdf:type schema:CreativeWork
    174 sg:pub.10.1038/ng0994-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029407853
    175 https://doi.org/10.1038/ng0994-15
    176 rdf:type schema:CreativeWork
    177 sg:pub.10.1038/ng0994-22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042277853
    178 https://doi.org/10.1038/ng0994-22
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1038/ng0994-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046920232
    181 https://doi.org/10.1038/ng0994-27
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1038/ng0994-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023732127
    184 https://doi.org/10.1038/ng0994-3
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1038/scientificamerican0988-44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056600892
    187 https://doi.org/10.1038/scientificamerican0988-44
    188 rdf:type schema:CreativeWork
    189 https://doi.org/10.1006/bbrc.1994.2090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030646059
    190 rdf:type schema:CreativeWork
    191 https://doi.org/10.1006/bbrc.1994.2294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007505285
    192 rdf:type schema:CreativeWork
    193 https://doi.org/10.1006/bbrc.1996.0045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006246307
    194 rdf:type schema:CreativeWork
    195 https://doi.org/10.1016/0092-8674(89)90429-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050439710
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1016/0092-8674(89)90949-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049470439
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1016/0092-8674(89)90975-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041796656
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1016/0092-8674(90)90188-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1039577503
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1016/0092-8674(90)90251-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054549979
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1016/0092-8674(91)90042-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1051296798
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1016/0092-8674(91)90100-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1034276940
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1016/0092-8674(91)90101-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011021705
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1016/0092-8674(92)90360-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1028885121
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1016/0092-8674(92)90518-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1009706637
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1016/0092-8674(93)90136-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1011690149
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1016/0092-8674(93)90499-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1034836400
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1016/0092-8674(93)90636-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009780866
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1016/0092-8674(93)90723-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006212321
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1016/0092-8674(94)90573-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015252677
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1016/0092-8674(95)90271-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020126871
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1016/0168-1656(94)90062-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037214734
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1016/0168-9525(88)90134-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049347128
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1016/0304-419x(90)90013-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1008481184
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1016/0888-7543(92)90126-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1052508633
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1016/0888-7543(92)90127-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1003171281
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1016/0955-0674(94)90142-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050629018
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1016/0958-1669(92)90084-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1004165446
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1056/nejm198605083141901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047504105
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1073/pnas.83.8.2438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048089140
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1073/pnas.84.24.9059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048059921
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1073/pnas.91.12.5291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035378612
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1073/pnas.91.23.11045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016446367
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1083/jcb.106.3.761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049975817
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1083/jcb.111.5.2129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037648739
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1083/jcb.119.5.1017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006628324
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1083/jcb.121.6.1397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024506408
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1089/dna.1994.13.343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059251346
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1091/mbc.4.9.897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033410916
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1093/protein/7.2.243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059981017
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1101/gad.7.3.331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000187410
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1101/gad.7.8.1559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015564012
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1101/gad.8.1.9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052772922
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1101/gad.8.24.2939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038530556
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1126/science.1439824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062482274
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1126/science.1659741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062497985
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1126/science.7652577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062648309
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1126/science.7667636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062648356
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1126/science.7809631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649804
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1126/science.7939631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062650650
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1126/science.8023167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652014
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1126/science.8073268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652144
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1126/science.8153613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652951
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1126/science.8153634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652972
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1126/science.8475385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062655746
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1128/mcb.13.8.5122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011616001
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1128/mcb.14.3.2077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013411441
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1128/mcb.15.5.2682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005110459
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1128/mcb.8.3.1247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048134605
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1146/annurev.cb.06.110190.003121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041319269
    304 rdf:type schema:CreativeWork
    305 https://www.grid.ac/institutes/grid.225279.9 schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...