Self-assembling multimeric nucleic acid constructs


Ontology type: sgo:Patent     


Patent Info

DATE

1999-10-12T00:00

AUTHORS

Charles R. Cantor , Christof M. Niemeyer , Cassandra L. Smith , Takeshi Sano , Donald J. Hnatowich , Mary Rusckowski

ABSTRACT

The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify diseased tissue or cells. Repeated administrations of multimeric nucleic acid compositions produce a rapid and specific amplification of nucleic acid constructs and their attached functional groups. For treatment purposes, functional groups may be toxins, radioisotopes, genes or enzymes. Diagnostically, labeled multimeric constructs may be used to identify specific targets in vivo or in vitro. Multimeric nucleic acids may also be used in nanotechnology and to create self-assembling polymeric aggregates such as membranes of defined porosity, microcircuits and many other products. More... »

Related SciGraph Publications

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2447", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Charles R. Cantor", 
        "type": "Person"
      }, 
      {
        "name": "Christof M. Niemeyer", 
        "type": "Person"
      }, 
      {
        "name": "Cassandra L. Smith", 
        "type": "Person"
      }, 
      {
        "name": "Takeshi Sano", 
        "type": "Person"
      }, 
      {
        "name": "Donald J. Hnatowich", 
        "type": "Person"
      }, 
      {
        "name": "Mary Rusckowski", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nbt1088-1165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005250317", 
          "https://doi.org/10.1038/nbt1088-1165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1050-3862(92)90005-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018813291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1050-3862(92)90005-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018813291"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-10-12T00:00", 
    "description": "

The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify diseased tissue or cells. Repeated administrations of multimeric nucleic acid compositions produce a rapid and specific amplification of nucleic acid constructs and their attached functional groups. For treatment purposes, functional groups may be toxins, radioisotopes, genes or enzymes. Diagnostically, labeled multimeric constructs may be used to identify specific targets in vivo or in vitro. Multimeric nucleic acids may also be used in nanotechnology and to create self-assembling polymeric aggregates such as membranes of defined porosity, microcircuits and many other products.

", "id": "sg:patent.US-5965133-A", "keywords": [ "self-assembling", "invention", "construct", "composition", "nucleic acid", "biotin", "streptavidin", "functional group", "vivo", "diseased tissue", "cell", "repeated administration", "amplification", "toxin", "Radioisotope", "gene", "enzyme", "specific target", "vitro", "nanotechnology", "aggregate", "membrane", "porosity", "microcircuit", "product" ], "name": "Self-assembling multimeric nucleic acid constructs", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.168645.8", "type": "Organization" }, { "id": "https://www.grid.ac/institutes/grid.189504.1", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-5965133-A" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:27", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_03064.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-5965133-A'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-5965133-A'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-5965133-A'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-5965133-A'


 

This table displays all metadata directly associated to this object as RDF triples.

76 TRIPLES      15 PREDICATES      42 URIs      33 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-5965133-A schema:about anzsrc-for:2447
2 schema:author N0aa30dd9ee3e4a84968bff6acce1c10f
3 schema:citation sg:pub.10.1038/nbt1088-1165
4 https://doi.org/10.1016/1050-3862(92)90005-p
5 schema:datePublished 1999-10-12T00:00
6 schema:description <p>The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify diseased tissue or cells. Repeated administrations of multimeric nucleic acid compositions produce a rapid and specific amplification of nucleic acid constructs and their attached functional groups. For treatment purposes, functional groups may be toxins, radioisotopes, genes or enzymes. Diagnostically, labeled multimeric constructs may be used to identify specific targets in vivo or in vitro. Multimeric nucleic acids may also be used in nanotechnology and to create self-assembling polymeric aggregates such as membranes of defined porosity, microcircuits and many other products.</p>
7 schema:keywords Radioisotope
8 aggregate
9 amplification
10 biotin
11 cell
12 composition
13 construct
14 diseased tissue
15 enzyme
16 functional group
17 gene
18 invention
19 membrane
20 microcircuit
21 nanotechnology
22 nucleic acid
23 porosity
24 product
25 repeated administration
26 self-assembling
27 specific target
28 streptavidin
29 toxin
30 vitro
31 vivo
32 schema:name Self-assembling multimeric nucleic acid constructs
33 schema:recipient https://www.grid.ac/institutes/grid.168645.8
34 https://www.grid.ac/institutes/grid.189504.1
35 schema:sameAs https://app.dimensions.ai/details/patent/US-5965133-A
36 schema:sdDatePublished 2019-04-18T10:27
37 schema:sdLicense https://scigraph.springernature.com/explorer/license/
38 schema:sdPublisher N42070c98b4624212a60b44b36842c11f
39 sgo:license sg:explorer/license/
40 sgo:sdDataset patents
41 rdf:type sgo:Patent
42 N0aa30dd9ee3e4a84968bff6acce1c10f rdf:first N20250393d09e41c7aa0e04fc0a926c6e
43 rdf:rest N3da18d3df49c4ad79232622be19d09f3
44 N17581cdaf19a4ce292f82bcf2e8de34b rdf:first Nf9b74b816b4d4759bfb79325f8226533
45 rdf:rest rdf:nil
46 N20250393d09e41c7aa0e04fc0a926c6e schema:name Charles R. Cantor
47 rdf:type schema:Person
48 N2161c1eb85574d9ead6243c986e6771a schema:name Donald J. Hnatowich
49 rdf:type schema:Person
50 N32acb9cbd7ec4631bc92ce7778616fd5 rdf:first N37f32b7c75ba4450960a241397d74110
51 rdf:rest N6d4485ad131a489ba257ee27294fac8d
52 N37bbdea8fc724ac08385f75ebbb23cff rdf:first N2161c1eb85574d9ead6243c986e6771a
53 rdf:rest N17581cdaf19a4ce292f82bcf2e8de34b
54 N37f32b7c75ba4450960a241397d74110 schema:name Cassandra L. Smith
55 rdf:type schema:Person
56 N3da18d3df49c4ad79232622be19d09f3 rdf:first N5db281b0a1ac433b8a433164d62aeada
57 rdf:rest N32acb9cbd7ec4631bc92ce7778616fd5
58 N42070c98b4624212a60b44b36842c11f schema:name Springer Nature - SN SciGraph project
59 rdf:type schema:Organization
60 N4da3cc038be2487282dc55170446b387 schema:name Takeshi Sano
61 rdf:type schema:Person
62 N5db281b0a1ac433b8a433164d62aeada schema:name Christof M. Niemeyer
63 rdf:type schema:Person
64 N6d4485ad131a489ba257ee27294fac8d rdf:first N4da3cc038be2487282dc55170446b387
65 rdf:rest N37bbdea8fc724ac08385f75ebbb23cff
66 Nf9b74b816b4d4759bfb79325f8226533 schema:name Mary Rusckowski
67 rdf:type schema:Person
68 anzsrc-for:2447 schema:inDefinedTermSet anzsrc-for:
69 rdf:type schema:DefinedTerm
70 sg:pub.10.1038/nbt1088-1165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005250317
71 https://doi.org/10.1038/nbt1088-1165
72 rdf:type schema:CreativeWork
73 https://doi.org/10.1016/1050-3862(92)90005-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1018813291
74 rdf:type schema:CreativeWork
75 https://www.grid.ac/institutes/grid.168645.8 schema:Organization
76 https://www.grid.ac/institutes/grid.189504.1 schema:Organization
 




Preview window. Press ESC to close (or click here)


...