Human til cells expressing recombinant TNF prohormone


Ontology type: sgo:Patent     


Patent Info

DATE

1999-02-23T00:00

AUTHORS

Michael Kriegler , Carl F. Perez

ABSTRACT

Tumor Infiltrating Lymphocyte (TIL) cells transformed with exogenous DNA encoding tumor necrosis factor (TNF) prohormone variants are disclosed. Among such variants are the TNF γ sig construct, which facilitates expression of the mature TNF polypeptide, and the noncleavable cytotoxic prohormone variants TNFΔ(1→12) and TNF(1+12). The transformed TIL cells are useful in antitumor therapy. More... »

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    Tumor Infiltrating Lymphocyte (TIL) cells transformed with exogenous DNA encoding tumor necrosis factor (TNF) prohormone variants are disclosed. Among such variants are the TNF γ sig construct, which facilitates expression of the mature TNF polypeptide, and the noncleavable cytotoxic prohormone variants TNFΔ(1→12) and TNF(1+12). The transformed TIL cells are useful in antitumor therapy.

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