Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors


Ontology type: sgo:Patent     


Patent Info

DATE

1999-02-02T00:00

AUTHORS

MARKOWITZ SANFORD D , BRATTAIN MICHAEL G , WILLSON JAMES K V

ABSTRACT

This invention is based on the discovery that the type II TGF- beta receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis. More... »

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