Ste20 Oxidant Stress Response Kinase, Nucleotide Sequence, Induces Cell Cycle Arrest


Ontology type: sgo:Patent     


Patent Info

DATE

1998-11-03T00:00

AUTHORS

FORCE THOMAS , KYRIAKIS JOHN M , POMBO CELIA M , BONVENTRE JOSEPH

ABSTRACT

A SOK polypeptide, an isolated DNA having a nucleotide sequence encoding a SOK polypeptide, and a method of determining whether a candidate compound modulates SOK-1 activity or expression, comprising the steps of providing a first and a second recombinant cell expressing a SOK gene; introducing a candidate compound into the first cell, but not into the second cell; measuring a SOK function in the first and second cells; and comparing the results obtained with the first and second SOK transformed cells, wherein an increase or decrease in the SOK function in the first cell compared to the second cell is an indication that the candidate compound modulates SOK expression or activity. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "FORCE THOMAS", 
        "type": "Person"
      }, 
      {
        "name": "KYRIAKIS JOHN M", 
        "type": "Person"
      }, 
      {
        "name": "POMBO CELIA M", 
        "type": "Person"
      }, 
      {
        "name": "BONVENTRE JOSEPH", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/377750a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031048693", 
          "https://doi.org/10.1038/377750a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01463929", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035381246", 
          "https://doi.org/10.1007/bf01463929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/369156a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029771272", 
          "https://doi.org/10.1038/369156a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007380735", 
          "https://doi.org/10.1038/sj.onc.1201043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/372794a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012539120", 
          "https://doi.org/10.1038/372794a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/367040a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021411105", 
          "https://doi.org/10.1038/367040a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/376785a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022545215", 
          "https://doi.org/10.1038/376785a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-11-03T00:00", 
    "description": "

A SOK polypeptide, an isolated DNA having a nucleotide sequence encoding a SOK polypeptide, and a method of determining whether a candidate compound modulates SOK-1 activity or expression, comprising the steps of providing a first and a second recombinant cell expressing a SOK gene; introducing a candidate compound into the first cell, but not into the second cell; measuring a SOK function in the first and second cells; and comparing the results obtained with the first and second SOK transformed cells, wherein an increase or decrease in the SOK function in the first cell compared to the second cell is an indication that the candidate compound modulates SOK expression or activity.

", "endDate": "2017-05-07", "id": "sg:patent.US-5830699-A", "name": "STE20 OXIDANT STRESS RESPONSE KINASE, NUCLEOTIDE SEQUENCE, INDUCES CELL CYCLE ARREST", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.32224.35", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-5830699-A" ], "sdDataset": "patents", "sdDatePublished": "2022-09-02T16:21", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/patent/patent_13.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-5830699-A'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-5830699-A'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-5830699-A'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-5830699-A'


 

This table displays all metadata directly associated to this object as RDF triples.

66 TRIPLES      15 PREDICATES      23 URIs      9 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-5830699-A schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N60895f4e617b4a5687ad42ae42220e80
4 schema:citation sg:pub.10.1007/bf01463929
5 sg:pub.10.1038/367040a0
6 sg:pub.10.1038/369156a0
7 sg:pub.10.1038/372794a0
8 sg:pub.10.1038/376785a0
9 sg:pub.10.1038/377750a0
10 sg:pub.10.1038/sj.onc.1201043
11 schema:datePublished 1998-11-03T00:00
12 schema:description <p>A SOK polypeptide, an isolated DNA having a nucleotide sequence encoding a SOK polypeptide, and a method of determining whether a candidate compound modulates SOK-1 activity or expression, comprising the steps of providing a first and a second recombinant cell expressing a SOK gene; introducing a candidate compound into the first cell, but not into the second cell; measuring a SOK function in the first and second cells; and comparing the results obtained with the first and second SOK transformed cells, wherein an increase or decrease in the SOK function in the first cell compared to the second cell is an indication that the candidate compound modulates SOK expression or activity.</p>
13 schema:endDate 2017-05-07
14 schema:name STE20 OXIDANT STRESS RESPONSE KINASE, NUCLEOTIDE SEQUENCE, INDUCES CELL CYCLE ARREST
15 schema:recipient grid-institutes:grid.32224.35
16 schema:sameAs https://app.dimensions.ai/details/patent/US-5830699-A
17 schema:sdDatePublished 2022-09-02T16:21
18 schema:sdLicense https://scigraph.springernature.com/explorer/license/
19 schema:sdPublisher N48f4fb1703d84499abba6add80a5b831
20 sgo:license sg:explorer/license/
21 sgo:sdDataset patents
22 rdf:type sgo:Patent
23 N354e317b409f4a31b12cccb86c96ee58 schema:name KYRIAKIS JOHN M
24 rdf:type schema:Person
25 N3d385f31685247dd8e4ef43e363b6b59 rdf:first N579b4905678241fa8231b8903b53d18d
26 rdf:rest Nce4479f242244b2583fc1aa711f88896
27 N48f4fb1703d84499abba6add80a5b831 schema:name Springer Nature - SN SciGraph project
28 rdf:type schema:Organization
29 N579b4905678241fa8231b8903b53d18d schema:name POMBO CELIA M
30 rdf:type schema:Person
31 N6018ec8754b548b0b0c7c269114199a1 rdf:first N354e317b409f4a31b12cccb86c96ee58
32 rdf:rest N3d385f31685247dd8e4ef43e363b6b59
33 N60895f4e617b4a5687ad42ae42220e80 rdf:first N90d52ada9414472998243f95f6ef461b
34 rdf:rest N6018ec8754b548b0b0c7c269114199a1
35 N6adbce2ecf114fc98d4d2e6f133b0daf schema:name BONVENTRE JOSEPH
36 rdf:type schema:Person
37 N90d52ada9414472998243f95f6ef461b schema:name FORCE THOMAS
38 rdf:type schema:Person
39 Nce4479f242244b2583fc1aa711f88896 rdf:first N6adbce2ecf114fc98d4d2e6f133b0daf
40 rdf:rest rdf:nil
41 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
42 rdf:type schema:DefinedTerm
43 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
44 rdf:type schema:DefinedTerm
45 sg:pub.10.1007/bf01463929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035381246
46 https://doi.org/10.1007/bf01463929
47 rdf:type schema:CreativeWork
48 sg:pub.10.1038/367040a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021411105
49 https://doi.org/10.1038/367040a0
50 rdf:type schema:CreativeWork
51 sg:pub.10.1038/369156a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029771272
52 https://doi.org/10.1038/369156a0
53 rdf:type schema:CreativeWork
54 sg:pub.10.1038/372794a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012539120
55 https://doi.org/10.1038/372794a0
56 rdf:type schema:CreativeWork
57 sg:pub.10.1038/376785a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022545215
58 https://doi.org/10.1038/376785a0
59 rdf:type schema:CreativeWork
60 sg:pub.10.1038/377750a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031048693
61 https://doi.org/10.1038/377750a0
62 rdf:type schema:CreativeWork
63 sg:pub.10.1038/sj.onc.1201043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007380735
64 https://doi.org/10.1038/sj.onc.1201043
65 rdf:type schema:CreativeWork
66 grid-institutes:grid.32224.35 schema:Organization
 




Preview window. Press ESC to close (or click here)


...