Protein-polycation nucleic acid complexes and methods of use


Ontology type: sgo:Patent     


Patent Info

DATE

1998-08-11T00:00

AUTHORS

BEUG HARTMUT DR , BIRNSTIEL MAX L PROF DR , COTTEN MATTHEW DR , WAGNER ERNST DR

ABSTRACT

The invention relates to a system for transporting nucleic acids into the cell, which is effected by receptor-mediated endocytosis. Using a transferrin-polycation conjugate, a complex can be formed with the polyanionic nucleic acid. This complex is bound to the transferrin receptor, which is highly regulated in growing cells, and absorbed into the cell. Suitable nucleic acids include those which inhibit specific genes or the RNA function, such as antisense oligonucleotides or ribozymes or the genes coding for them. The invention further relates to a process for introducing nucleic acids into the cells, transferrin-polycation/nucleic acid complexes and pharmaceutical preparations containing them. More... »

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