Method for obtaining RNA aptamers based on shape selection


Ontology type: sgo:Patent     


Patent Info

DATE

1998-08-11T00:00

AUTHORS

Francis J. Schmidt , Bongrae Cho , Hugh B. Nicholas, Jr.

ABSTRACT

RNA molecules are selected from a random sequence library for their ability to bind to a selecting nucleic acid structural element. Selection of RNA aptamers with extensive Watson-Crick complementarity to the nucleic acid ligand is precluded by inclusion of a blocking oligodeoxynucleotide in the binding phase of the selection protocol.

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