Modified recombinant vaccinia virus and expression vectors thereof


Ontology type: sgo:Patent     


Patent Info

DATE

1998-06-09T00:00

AUTHORS

Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe Francis Audonnet , Russell Robert Gettig

ABSTRACT

What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines. More... »

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