Chimeric cytokine receptors in lymphocytes


Ontology type: sgo:Patent     


Patent Info

DATE

1998-05-05T00:00

AUTHORS

Philip D. Greenberg , Brad H. Nelson

ABSTRACT

Recombinant polynucleotides are provided that encode chimeric cytokine receptors. The chimeric receptor is comprised of an extracellular domain derived from cytokine receptor A-R that binds cytokine A, used to a transmembrane and cytoplasmic domain derived from cytokine receptor B-R that binds cytokine B. When the chimeric receptor is expressed in a lymphocyte it lessens the growth dependency of the lymphocyte on cytokine B in the presence of cytokine A. More... »

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