Modified subtilisins having amino acid alterations


Ontology type: sgo:Patent     


Patent Info

DATE

1997-12-23T00:00

AUTHORS

Richard Ray Bott , Robert Mark Caldwell , Brian C. Cunningham , David Aaron Estell , Scott Douglas Power , James Allen Wells

ABSTRACT

Novel carbonyl hydrolase mutants derived from the amino acid sequence of naturally-occurring or recombinant non-human carbonyl hydrolases and DNA sequences encoding the same. The mutant carbonyl hydrolases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant carbonyl hydrolase to encode the substitution, insertion or deletion of one or more amino acids in the amino acid sequence of a precursor carbonyl hydrolase. Such mutants have one or more properties which are different than the same property of the precursor hydrolase. More... »

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