Modular assembly of antibody genes, antibodies prepared thereby and use


Ontology type: sgo:Patent     


Patent Info

DATE

1997-12-16T00:00

AUTHORS

Randy R. Robinson , Alvin Y. Liu , Arnold H. Horwitz , Marc Better , Randolph Wall , Shau-Ping Lei , Gary L. Wilcox

ABSTRACT

The invention relates to cDNA genetic sequences, vehicles containing same as well as hosts transformed therewith, for the production of chimeric immunoglobulin molecules, functional fragments thereof and immunoglobulin derivatives exhibiting novel functional properties comprising human constant region modules and non-human variable region modules, or for class switching antibody molecules and/or chains. The invention also relates to DNA coding for pectate lyase signal peptide has been cloned on a plasmid to create a secretion vector which is capable of producing a chosen protein which is transported across the bacterial membrane. The secretion vector has been used to secrete extracellular thaumatin and extracellular chimeric antibody fragments. The proteins produced by this vector have biological activity. The thaumatin is properly folded and the antibody fragments are capable of binding antigens on target cancer cells. The invention also relates to the secretion of chimeric antibodies and fragments thereof from yeast in functional form. More... »

Related SciGraph Publications

  • 1989-10. Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli in NATURE
  • 1988-02. Secretion of Human Superoxide Dismutase in Escherichia Coli in NATURE BIOTECHNOLOGY
  • 1984-12. Recombinant antibodies possessing novel effector functions in NATURE
  • 1993-02. A Thioredoxin Gene Fusion Expression System That Circumvents Inclusion Body Formation in the E. coli Cytoplasm in BIO/TECHNOLOGY
  • 1982-02. Structural alterations in J regions of mouse immunoglobulin λ genes are associated with differential gene expression in NATURE
  • 1992-02. High-Level Expression of a Recombinant Antibody from Myeloma Cells Using a Glutamine Synthetase Gene as an Amplifiable Selectable Marker in BIO/TECHNOLOGY
  • 1989-11. Production of Soluble Recombinant Proteins in Bacteria in NATURE BIOTECHNOLOGY
  • 1986-11. High–Level Expression, Efficient Secretion and Folding of Human Growth Hormone in Escherichia coli in NATURE BIOTECHNOLOGY
  • 1983-10. Nucleotide sequence of a rabbit IgG heavy chain from the recombinant F-I haplotype in IMMUNOGENETICS
  • 1983-07. Genentech Makes Monoclonal Precursors from E. coli in NATURE BIOTECHNOLOGY
  • 1986-05. Secretion of Proteins from Bacteria in NATURE BIOTECHNOLOGY
  • 1992-02. High Level Escherichia coli Expression and Production of a Bivalent Humanized Antibody Fragment in BIO/TECHNOLOGY
  • 1985-04. The synthesis and in vivo assembly of functional antibodies in yeast in NATURE
  • 1986-05. Replacing the complementarity-determining regions in a human antibody with those from a mouse in NATURE
  • 1984-05. Expression of a VHCκ chimaeric protein in mouse myeloma cells in NATURE
  • 1991-06. Antibody Engineering: Advances From the Use of Escherichia coli Expression Systems in BIO/TECHNOLOGY
  • 1985-04. Construction of chimaeric processed immunoglobulin genes containing mouse variable and human constant region sequences in NATURE
  • 1984-12. Production of functional chimaeric mouse/human antibody in NATURE
  • 1979-07. Sequences at the somatic recombination sites of immunoglobulin light-chain genes in NATURE
  • 1991-08. Making antibody fragments using phage display libraries in NATURE
  • 1985-03. A hapten-specific chimaeric IgE antibody with human physiological effector function in NATURE
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2581", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "Randy R. Robinson", 
            "type": "Person"
          }, 
          {
            "name": "Alvin Y. Liu", 
            "type": "Person"
          }, 
          {
            "name": "Arnold H. Horwitz", 
            "type": "Person"
          }, 
          {
            "name": "Marc Better", 
            "type": "Person"
          }, 
          {
            "name": "Randolph Wall", 
            "type": "Person"
          }, 
          {
            "name": "Shau-Ping Lei", 
            "type": "Person"
          }, 
          {
            "name": "Gary L. Wilcox", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.82.21.7212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000867620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.77.10.6027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001456003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(85)90158-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001586631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(85)90158-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001586631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/11.10.3077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002579895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/314452a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002617725", 
              "https://doi.org/10.1038/314452a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.90.2.457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003453586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/314446a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003708008", 
              "https://doi.org/10.1038/314446a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.81.10.2955", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004813836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(86)90177-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005175807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(86)90177-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005175807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.79.10.3260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005927118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.88.18.7978", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007504748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/321522a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007617918", 
              "https://doi.org/10.1038/321522a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/10.13.4071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009759590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(85)90319-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009888127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(85)90319-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009888127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.87.20.8095", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010117827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.81.15.4756", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010502436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.78.9.5401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010982777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(83)90015-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011572629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(91)90347-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011927126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(91)90347-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011927126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0783-396", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012579673", 
              "https://doi.org/10.1038/nbt0783-396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/12.13.5145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013296673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/12.22.8407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013927868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0691-545", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014209564", 
              "https://doi.org/10.1038/nbt0691-545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(85)90288-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016169745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(85)90288-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016169745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(80)90168-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016442666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.76.7.3450", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017285571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(82)90183-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017559045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/312643a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017996216", 
              "https://doi.org/10.1038/312643a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1186-991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019022620", 
              "https://doi.org/10.1038/nbt1186-991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.85.22.8678", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019050103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.iy.10.040192.001323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019341821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/309364a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019506442", 
              "https://doi.org/10.1038/309364a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(83)90016-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020377018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/12.13.5307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021028414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/352624a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021945431", 
              "https://doi.org/10.1038/352624a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1189-1141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022215653", 
              "https://doi.org/10.1038/nbt1189-1141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.81.17.5369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022253016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.84.10.3439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022927453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.75.12.5936", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025056597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/295428a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026193357", 
              "https://doi.org/10.1038/295428a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.bi.53.070184.001543", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026445209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/314268a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027818224", 
              "https://doi.org/10.1038/314268a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(85)90121-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028380138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(85)90121-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028380138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(87)90344-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029685380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(87)90344-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029685380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.81.21.6851", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030102558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/341544a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030400388", 
              "https://doi.org/10.1038/341544a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/14.18.7487", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035951684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(81)90400-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036104428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.81.11.3273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036454501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(82)90050-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036729029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(82)90050-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036729029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.85.20.7685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037413272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/12.9.3791", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038281449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00372471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039346219", 
              "https://doi.org/10.1007/bf00372471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00372471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039346219", 
              "https://doi.org/10.1007/bf00372471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(87)90470-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039970957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/9.2.309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040425653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.82.2.556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040431900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0288-195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040798202", 
              "https://doi.org/10.1038/nbt0288-195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(84)90076-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040910941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(84)90076-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040910941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(81)90325-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041884756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/11.3.719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042722577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.80.20.6351", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043356466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(87)90487-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043420587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.83.22.8506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043678507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.86.15.5728", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044057676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(86)90223-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045229577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(86)90223-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045229577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/12.24.9441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046230404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.63.1.78", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047016203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/312604a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047097780", 
              "https://doi.org/10.1038/312604a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0293-187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047369791", 
              "https://doi.org/10.1038/nbt0293-187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.84.1.214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047951642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(80)90321-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048325973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0292-163", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048787453", 
              "https://doi.org/10.1038/nbt0292-163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(92)90499-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048788541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(92)90499-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048788541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0586-427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049904337", 
              "https://doi.org/10.1038/nbt0586-427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0292-169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050143048", 
              "https://doi.org/10.1038/nbt0292-169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.86.10.3833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050847096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(89)90444-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051318300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(89)90444-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051318300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.80.10.3015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051906441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.79.6.1984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051914823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/280288a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052104343", 
              "https://doi.org/10.1038/280288a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(79)90009-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052801969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(79)90009-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052801969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(83)90014-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054549935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00121a001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055161662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/protein/2.3.169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059980398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/protein/4.8.971", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059980697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/protein/6.8.981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059980940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/protein/7.6.805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059981086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2531466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062542740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3285470", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062604296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3285471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062604297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3929380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062622558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.4012325", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062623757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jb.168.2.595-606.1986", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062715267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jb.169.12.5339-5342.1987", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062715612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jb.169.4.1386-1390.1987", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062715852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jb.169.9.4379-4383.1987", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062716324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1985.tb03659.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079429969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1985.tb03741.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079496513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1987.tb02580.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079564763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1987.tb04825.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079819482"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1997-12-16T00:00", 
        "description": "

    The invention relates to cDNA genetic sequences, vehicles containing same as well as hosts transformed therewith, for the production of chimeric immunoglobulin molecules, functional fragments thereof and immunoglobulin derivatives exhibiting novel functional properties comprising human constant region modules and non-human variable region modules, or for class switching antibody molecules and/or chains. The invention also relates to DNA coding for pectate lyase signal peptide has been cloned on a plasmid to create a secretion vector which is capable of producing a chosen protein which is transported across the bacterial membrane. The secretion vector has been used to secrete extracellular thaumatin and extracellular chimeric antibody fragments. The proteins produced by this vector have biological activity. The thaumatin is properly folded and the antibody fragments are capable of binding antigens on target cancer cells. The invention also relates to the secretion of chimeric antibodies and fragments thereof from yeast in functional form.

    ", "id": "sg:patent.US-5698435-A", "keywords": [ "assembly", "antibody gene", "antibody", "invention", "genetic sequence", "vehicle", "host", "immunoglobulin molecule", "fragment", "immunoglobulin", "functional property", "constant region", "variable region", "antibody molecule", "chain", "DNA coding", "pectate lyase", "plasmid", "vector", "protein", "bacterial membrane", "chimeric antibody", "biological activity", "antibody fragment", "binding", "target cancer cell", "Bodily Secretion", "yeast", "functional form" ], "name": "Modular assembly of antibody genes, antibodies prepared thereby and use", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.420220.6", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-5698435-A" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:26", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_03036.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-5698435-A'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-5698435-A'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-5698435-A'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-5698435-A'


     

    This table displays all metadata directly associated to this object as RDF triples.

    396 TRIPLES      15 PREDICATES      143 URIs      37 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-5698435-A schema:about anzsrc-for:2581
    2 schema:author Nfaf9d2e858704c549f61c147e6a2e483
    3 schema:citation sg:pub.10.1007/bf00372471
    4 sg:pub.10.1038/280288a0
    5 sg:pub.10.1038/295428a0
    6 sg:pub.10.1038/309364a0
    7 sg:pub.10.1038/312604a0
    8 sg:pub.10.1038/312643a0
    9 sg:pub.10.1038/314268a0
    10 sg:pub.10.1038/314446a0
    11 sg:pub.10.1038/314452a0
    12 sg:pub.10.1038/321522a0
    13 sg:pub.10.1038/341544a0
    14 sg:pub.10.1038/352624a0
    15 sg:pub.10.1038/nbt0288-195
    16 sg:pub.10.1038/nbt0292-163
    17 sg:pub.10.1038/nbt0292-169
    18 sg:pub.10.1038/nbt0293-187
    19 sg:pub.10.1038/nbt0586-427
    20 sg:pub.10.1038/nbt0691-545
    21 sg:pub.10.1038/nbt0783-396
    22 sg:pub.10.1038/nbt1186-991
    23 sg:pub.10.1038/nbt1189-1141
    24 https://doi.org/10.1002/j.1460-2075.1985.tb03659.x
    25 https://doi.org/10.1002/j.1460-2075.1985.tb03741.x
    26 https://doi.org/10.1002/j.1460-2075.1987.tb02580.x
    27 https://doi.org/10.1002/j.1460-2075.1987.tb04825.x
    28 https://doi.org/10.1016/0092-8674(80)90168-3
    29 https://doi.org/10.1016/0092-8674(80)90321-9
    30 https://doi.org/10.1016/0092-8674(81)90325-1
    31 https://doi.org/10.1016/0092-8674(81)90400-1
    32 https://doi.org/10.1016/0092-8674(82)90183-0
    33 https://doi.org/10.1016/0092-8674(83)90014-4
    34 https://doi.org/10.1016/0092-8674(83)90015-6
    35 https://doi.org/10.1016/0092-8674(83)90016-8
    36 https://doi.org/10.1016/0378-1119(79)90009-x
    37 https://doi.org/10.1016/0378-1119(82)90050-6
    38 https://doi.org/10.1016/0378-1119(84)90076-3
    39 https://doi.org/10.1016/0378-1119(85)90121-0
    40 https://doi.org/10.1016/0378-1119(85)90158-1
    41 https://doi.org/10.1016/0378-1119(85)90288-4
    42 https://doi.org/10.1016/0378-1119(85)90319-1
    43 https://doi.org/10.1016/0378-1119(86)90177-0
    44 https://doi.org/10.1016/0378-1119(86)90223-4
    45 https://doi.org/10.1016/0378-1119(87)90344-1
    46 https://doi.org/10.1016/0378-1119(87)90470-7
    47 https://doi.org/10.1016/0378-1119(87)90487-2
    48 https://doi.org/10.1016/0378-1119(89)90444-7
    49 https://doi.org/10.1016/0378-1119(91)90347-e
    50 https://doi.org/10.1016/0378-1119(92)90499-f
    51 https://doi.org/10.1021/bi00121a001
    52 https://doi.org/10.1073/pnas.63.1.78
    53 https://doi.org/10.1073/pnas.75.12.5936
    54 https://doi.org/10.1073/pnas.76.7.3450
    55 https://doi.org/10.1073/pnas.77.10.6027
    56 https://doi.org/10.1073/pnas.78.9.5401
    57 https://doi.org/10.1073/pnas.79.10.3260
    58 https://doi.org/10.1073/pnas.79.6.1984
    59 https://doi.org/10.1073/pnas.80.10.3015
    60 https://doi.org/10.1073/pnas.80.20.6351
    61 https://doi.org/10.1073/pnas.81.10.2955
    62 https://doi.org/10.1073/pnas.81.11.3273
    63 https://doi.org/10.1073/pnas.81.15.4756
    64 https://doi.org/10.1073/pnas.81.17.5369
    65 https://doi.org/10.1073/pnas.81.21.6851
    66 https://doi.org/10.1073/pnas.82.2.556
    67 https://doi.org/10.1073/pnas.82.21.7212
    68 https://doi.org/10.1073/pnas.83.22.8506
    69 https://doi.org/10.1073/pnas.84.1.214
    70 https://doi.org/10.1073/pnas.84.10.3439
    71 https://doi.org/10.1073/pnas.85.20.7685
    72 https://doi.org/10.1073/pnas.85.22.8678
    73 https://doi.org/10.1073/pnas.86.10.3833
    74 https://doi.org/10.1073/pnas.86.15.5728
    75 https://doi.org/10.1073/pnas.87.20.8095
    76 https://doi.org/10.1073/pnas.88.18.7978
    77 https://doi.org/10.1073/pnas.90.2.457
    78 https://doi.org/10.1093/nar/10.13.4071
    79 https://doi.org/10.1093/nar/11.10.3077
    80 https://doi.org/10.1093/nar/11.3.719
    81 https://doi.org/10.1093/nar/12.13.5145
    82 https://doi.org/10.1093/nar/12.13.5307
    83 https://doi.org/10.1093/nar/12.22.8407
    84 https://doi.org/10.1093/nar/12.24.9441
    85 https://doi.org/10.1093/nar/12.9.3791
    86 https://doi.org/10.1093/nar/14.18.7487
    87 https://doi.org/10.1093/nar/9.2.309
    88 https://doi.org/10.1093/protein/2.3.169
    89 https://doi.org/10.1093/protein/4.8.971
    90 https://doi.org/10.1093/protein/6.8.981
    91 https://doi.org/10.1093/protein/7.6.805
    92 https://doi.org/10.1126/science.2531466
    93 https://doi.org/10.1126/science.3285470
    94 https://doi.org/10.1126/science.3285471
    95 https://doi.org/10.1126/science.3929380
    96 https://doi.org/10.1126/science.4012325
    97 https://doi.org/10.1128/jb.168.2.595-606.1986
    98 https://doi.org/10.1128/jb.169.12.5339-5342.1987
    99 https://doi.org/10.1128/jb.169.4.1386-1390.1987
    100 https://doi.org/10.1128/jb.169.9.4379-4383.1987
    101 https://doi.org/10.1146/annurev.bi.53.070184.001543
    102 https://doi.org/10.1146/annurev.iy.10.040192.001323
    103 schema:datePublished 1997-12-16T00:00
    104 schema:description <p>The invention relates to cDNA genetic sequences, vehicles containing same as well as hosts transformed therewith, for the production of chimeric immunoglobulin molecules, functional fragments thereof and immunoglobulin derivatives exhibiting novel functional properties comprising human constant region modules and non-human variable region modules, or for class switching antibody molecules and/or chains. The invention also relates to DNA coding for pectate lyase signal peptide has been cloned on a plasmid to create a secretion vector which is capable of producing a chosen protein which is transported across the bacterial membrane. The secretion vector has been used to secrete extracellular thaumatin and extracellular chimeric antibody fragments. The proteins produced by this vector have biological activity. The thaumatin is properly folded and the antibody fragments are capable of binding antigens on target cancer cells. The invention also relates to the secretion of chimeric antibodies and fragments thereof from yeast in functional form.</p>
    105 schema:keywords Bodily Secretion
    106 DNA coding
    107 antibody
    108 antibody fragment
    109 antibody gene
    110 antibody molecule
    111 assembly
    112 bacterial membrane
    113 binding
    114 biological activity
    115 chain
    116 chimeric antibody
    117 constant region
    118 fragment
    119 functional form
    120 functional property
    121 genetic sequence
    122 host
    123 immunoglobulin
    124 immunoglobulin molecule
    125 invention
    126 pectate lyase
    127 plasmid
    128 protein
    129 target cancer cell
    130 variable region
    131 vector
    132 vehicle
    133 yeast
    134 schema:name Modular assembly of antibody genes, antibodies prepared thereby and use
    135 schema:recipient https://www.grid.ac/institutes/grid.420220.6
    136 schema:sameAs https://app.dimensions.ai/details/patent/US-5698435-A
    137 schema:sdDatePublished 2019-04-18T10:26
    138 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    139 schema:sdPublisher N4b6260b0f18c47d1a4839d58ac05eaea
    140 sgo:license sg:explorer/license/
    141 sgo:sdDataset patents
    142 rdf:type sgo:Patent
    143 N13cf2333fa514270b0e915796b68768e rdf:first N37bfd13e0bfd4ef3970a8ca7e24f0a12
    144 rdf:rest rdf:nil
    145 N351a5d678033417cb620b70638f9402c rdf:first N3ccbd85efa7244c3a212096a909e5152
    146 rdf:rest N13cf2333fa514270b0e915796b68768e
    147 N37bfd13e0bfd4ef3970a8ca7e24f0a12 schema:name Gary L. Wilcox
    148 rdf:type schema:Person
    149 N3b8130edeac34388bebbf8710dc7d1c4 rdf:first Nfb23ae89328344ff946ae1419cb7ef37
    150 rdf:rest N351a5d678033417cb620b70638f9402c
    151 N3ccbd85efa7244c3a212096a909e5152 schema:name Shau-Ping Lei
    152 rdf:type schema:Person
    153 N4b6260b0f18c47d1a4839d58ac05eaea schema:name Springer Nature - SN SciGraph project
    154 rdf:type schema:Organization
    155 N6e89c521f1a34e35afa6e36162139bc7 schema:name Alvin Y. Liu
    156 rdf:type schema:Person
    157 N8bcbc629b5e54e378cbb01a16cbe346d rdf:first N6e89c521f1a34e35afa6e36162139bc7
    158 rdf:rest Ndcb7e273f9ef4db58da1e644f6682abd
    159 N8c5a2d368314430196515e6f1fc9ea35 schema:name Randy R. Robinson
    160 rdf:type schema:Person
    161 Na1dfb3fb00524b878df2b7d95c8ee216 schema:name Arnold H. Horwitz
    162 rdf:type schema:Person
    163 Ndcb7e273f9ef4db58da1e644f6682abd rdf:first Na1dfb3fb00524b878df2b7d95c8ee216
    164 rdf:rest Nee5172c30d80490b961d484bc7634d3e
    165 Nee5172c30d80490b961d484bc7634d3e rdf:first Nf46b6c79523e49f18b91d60609217219
    166 rdf:rest N3b8130edeac34388bebbf8710dc7d1c4
    167 Nf46b6c79523e49f18b91d60609217219 schema:name Marc Better
    168 rdf:type schema:Person
    169 Nfaf9d2e858704c549f61c147e6a2e483 rdf:first N8c5a2d368314430196515e6f1fc9ea35
    170 rdf:rest N8bcbc629b5e54e378cbb01a16cbe346d
    171 Nfb23ae89328344ff946ae1419cb7ef37 schema:name Randolph Wall
    172 rdf:type schema:Person
    173 anzsrc-for:2581 schema:inDefinedTermSet anzsrc-for:
    174 rdf:type schema:DefinedTerm
    175 sg:pub.10.1007/bf00372471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039346219
    176 https://doi.org/10.1007/bf00372471
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1038/280288a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052104343
    179 https://doi.org/10.1038/280288a0
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1038/295428a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026193357
    182 https://doi.org/10.1038/295428a0
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1038/309364a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019506442
    185 https://doi.org/10.1038/309364a0
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1038/312604a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047097780
    188 https://doi.org/10.1038/312604a0
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/312643a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017996216
    191 https://doi.org/10.1038/312643a0
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/314268a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027818224
    194 https://doi.org/10.1038/314268a0
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/314446a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003708008
    197 https://doi.org/10.1038/314446a0
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/314452a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002617725
    200 https://doi.org/10.1038/314452a0
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/321522a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007617918
    203 https://doi.org/10.1038/321522a0
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/341544a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030400388
    206 https://doi.org/10.1038/341544a0
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/352624a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021945431
    209 https://doi.org/10.1038/352624a0
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/nbt0288-195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040798202
    212 https://doi.org/10.1038/nbt0288-195
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/nbt0292-163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048787453
    215 https://doi.org/10.1038/nbt0292-163
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/nbt0292-169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050143048
    218 https://doi.org/10.1038/nbt0292-169
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/nbt0293-187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047369791
    221 https://doi.org/10.1038/nbt0293-187
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/nbt0586-427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049904337
    224 https://doi.org/10.1038/nbt0586-427
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/nbt0691-545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014209564
    227 https://doi.org/10.1038/nbt0691-545
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/nbt0783-396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012579673
    230 https://doi.org/10.1038/nbt0783-396
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/nbt1186-991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019022620
    233 https://doi.org/10.1038/nbt1186-991
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/nbt1189-1141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022215653
    236 https://doi.org/10.1038/nbt1189-1141
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1002/j.1460-2075.1985.tb03659.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079429969
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1002/j.1460-2075.1985.tb03741.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079496513
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1002/j.1460-2075.1987.tb02580.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079564763
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1002/j.1460-2075.1987.tb04825.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079819482
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/0092-8674(80)90168-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016442666
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/0092-8674(80)90321-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048325973
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/0092-8674(81)90325-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041884756
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/0092-8674(81)90400-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036104428
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/0092-8674(82)90183-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017559045
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/0092-8674(83)90014-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054549935
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/0092-8674(83)90015-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011572629
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/0092-8674(83)90016-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020377018
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1016/0378-1119(79)90009-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052801969
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/0378-1119(82)90050-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036729029
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/0378-1119(84)90076-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040910941
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/0378-1119(85)90121-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028380138
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/0378-1119(85)90158-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001586631
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/0378-1119(85)90288-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016169745
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/0378-1119(85)90319-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009888127
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/0378-1119(86)90177-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005175807
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/0378-1119(86)90223-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045229577
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/0378-1119(87)90344-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029685380
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/0378-1119(87)90470-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039970957
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/0378-1119(87)90487-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043420587
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/0378-1119(89)90444-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051318300
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/0378-1119(91)90347-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1011927126
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/0378-1119(92)90499-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1048788541
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1021/bi00121a001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055161662
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1073/pnas.63.1.78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047016203
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1073/pnas.75.12.5936 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025056597
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1073/pnas.76.7.3450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017285571
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1073/pnas.77.10.6027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001456003
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1073/pnas.78.9.5401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010982777
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1073/pnas.79.10.3260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005927118
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1073/pnas.79.6.1984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051914823
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1073/pnas.80.10.3015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051906441
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1073/pnas.80.20.6351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043356466
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1073/pnas.81.10.2955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004813836
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1073/pnas.81.11.3273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036454501
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1073/pnas.81.15.4756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010502436
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1073/pnas.81.17.5369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022253016
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1073/pnas.81.21.6851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030102558
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1073/pnas.82.2.556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040431900
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1073/pnas.82.21.7212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000867620
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1073/pnas.83.22.8506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043678507
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1073/pnas.84.1.214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047951642
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1073/pnas.84.10.3439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022927453
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1073/pnas.85.20.7685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037413272
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1073/pnas.85.22.8678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019050103
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1073/pnas.86.10.3833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050847096
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1073/pnas.86.15.5728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044057676
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1073/pnas.87.20.8095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010117827
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1073/pnas.88.18.7978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007504748
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1073/pnas.90.2.457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003453586
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1093/nar/10.13.4071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009759590
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1093/nar/11.10.3077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002579895
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1093/nar/11.3.719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042722577
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1093/nar/12.13.5145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013296673
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1093/nar/12.13.5307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021028414
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1093/nar/12.22.8407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013927868
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1093/nar/12.24.9441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046230404
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1093/nar/12.9.3791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038281449
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1093/nar/14.18.7487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035951684
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1093/nar/9.2.309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040425653
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1093/protein/2.3.169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059980398
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1093/protein/4.8.971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059980697
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1093/protein/6.8.981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059980940
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1093/protein/7.6.805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059981086
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1126/science.2531466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062542740
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1126/science.3285470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062604296
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1126/science.3285471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062604297
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1126/science.3929380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062622558
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1126/science.4012325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062623757
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1128/jb.168.2.595-606.1986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062715267
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1128/jb.169.12.5339-5342.1987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062715612
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1128/jb.169.4.1386-1390.1987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062715852
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1128/jb.169.9.4379-4383.1987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062716324
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1146/annurev.bi.53.070184.001543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026445209
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1146/annurev.iy.10.040192.001323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019341821
    395 rdf:type schema:CreativeWork
    396 https://www.grid.ac/institutes/grid.420220.6 schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...