Replication-defective adenovirus human type 5 recombinant as a rabies vaccine carrier


Ontology type: sgo:Patent     


Patent Info

DATE

1997-12-16T00:00

AUTHORS

Hildegund C. J. Ertl , James M. Wilson

ABSTRACT

A method of vaccinating a human or animal against rabies is provided by administering a replication defective recombinant adenovirus containing a complete deletion of its E1 gene and at least a partial deletion of its E3 gene, said virus containing in the site of the E1 deletion a sequence comprising a non-adenovirus promoter directing the replication and expression of DNA encoding a rabies virus G protein, which, when administered to the animal or human in said recombinant virus, elicits a substantially complete protective immune response against rabies virus. More... »

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