Peptide plasminogen activators


Ontology type: sgo:Patent     


Patent Info

DATE

1997-08-12T00:00

AUTHORS

Nancy L. Haigwood , Guy Mullenbach , Ernst-Guenter Afting , Eric Paul Paques

ABSTRACT

Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, reduced fibrin stimulation of plasminogenolytic activity and/or enhanced affinity to fibrin surfaces are provided by modifying the C-terminus by deletions.

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