Genetically engineered vaccine strain


Ontology type: sgo:Patent     


Patent Info

DATE

1994-11-15T00:00

AUTHORS

Enzo Paoletti , Marion E. Perkus

ABSTRACT

What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines. More... »

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What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.

", "id": "sg:patent.US-5364773-A", "keywords": [ "vaccine strain", "vector", "poxvirus", "recombinant vaccinia virus", "enhanced safety", "recombinant virus", "genetic function", "virus", "virulence", "embodiment", "open reading frame", "virulence factor", "insertional inactivation", "vaccine", "increased level", "safety" ], "name": "Genetically engineered vaccine strain", "sameAs": [ "https://app.dimensions.ai/details/patent/US-5364773-A" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:26", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_03003.jsonl", "type": "Patent" } ]
 

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