Chimeric antibodies


Ontology type: sgo:Patent     


Patent Info

DATE

1992-12-08T00:00

AUTHORS

Malcolm L. Gefter , Mark Ptashne , Jacqueline Sharon

ABSTRACT

Chimeric antibodies comprised of the variable region of an antibody chain contiguous with a polypeptide other than the constant region of that antibody chain are disclosed. Such chimeric antibodies can be comprised of the variable region of a chain of an immunoglobulin of selected specificity and an extrinsic polypeptide. In addition to the variable region of a chain of an immunoglobulin of selected specifity and an extrinsic polypeptide, the chimeric antibodies can include at least a portion of the constant region of an immunoglobFUNDING SOURCESThe work described herein was supported by grants from the National Institutes of Health, the American Cancer Society and the Damon Runyon--Walter Winchell Cancer Fund. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Malcolm L. Gefter", 
        "type": "Person"
      }, 
      {
        "name": "Mark Ptashne", 
        "type": "Person"
      }, 
      {
        "name": "Jacqueline Sharon", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/312643a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017996216", 
          "https://doi.org/10.1038/312643a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/309364a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019506442", 
          "https://doi.org/10.1038/309364a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.81.21.6851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030102558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.80.3.825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036904999"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1992-12-08T00:00", 
    "description": "

Chimeric antibodies comprised of the variable region of an antibody chain contiguous with a polypeptide other than the constant region of that antibody chain are disclosed. Such chimeric antibodies can be comprised of the variable region of a chain of an immunoglobulin of selected specificity and an extrinsic polypeptide. In addition to the variable region of a chain of an immunoglobulin of selected specifity and an extrinsic polypeptide, the chimeric antibodies can include at least a portion of the constant region of an immunoglob

FUNDING SOURCES

The work described herein was supported by grants from the National Institutes of Health, the American Cancer Society and the Damon Runyon--Walter Winchell Cancer Fund.

", "id": "sg:patent.US-5169939-A", "keywords": [ "chimeric antibody", "variable region", "antibody", "polypeptide", "constant region", "chain", "immunoglobulin", "portion", "funding source", "National Institute of Health", "American Cancer Society" ], "name": "Chimeric antibodies", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.116068.8", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-5169939-A" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:26", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_02985.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-5169939-A'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-5169939-A'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-5169939-A'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-5169939-A'


 

This table displays all metadata directly associated to this object as RDF triples.

55 TRIPLES      15 PREDICATES      29 URIs      19 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-5169939-A schema:about anzsrc-for:3103
2 schema:author Nf006e63c4cf4497dbd1e8b56c84a1668
3 schema:citation sg:pub.10.1038/309364a0
4 sg:pub.10.1038/312643a0
5 https://doi.org/10.1073/pnas.80.3.825
6 https://doi.org/10.1073/pnas.81.21.6851
7 schema:datePublished 1992-12-08T00:00
8 schema:description <p>Chimeric antibodies comprised of the variable region of an antibody chain contiguous with a polypeptide other than the constant region of that antibody chain are disclosed. Such chimeric antibodies can be comprised of the variable region of a chain of an immunoglobulin of selected specificity and an extrinsic polypeptide. In addition to the variable region of a chain of an immunoglobulin of selected specifity and an extrinsic polypeptide, the chimeric antibodies can include at least a portion of the constant region of an immunoglob</p><heading>FUNDING SOURCES</heading><p>The work described herein was supported by grants from the National Institutes of Health, the American Cancer Society and the Damon Runyon--Walter Winchell Cancer Fund.</p>
9 schema:keywords American Cancer Society
10 National Institute of Health
11 antibody
12 chain
13 chimeric antibody
14 constant region
15 funding source
16 immunoglobulin
17 polypeptide
18 portion
19 variable region
20 schema:name Chimeric antibodies
21 schema:recipient https://www.grid.ac/institutes/grid.116068.8
22 schema:sameAs https://app.dimensions.ai/details/patent/US-5169939-A
23 schema:sdDatePublished 2019-04-18T10:26
24 schema:sdLicense https://scigraph.springernature.com/explorer/license/
25 schema:sdPublisher Naa6d429eede8401b9de01cc3c9bf5ca0
26 sgo:license sg:explorer/license/
27 sgo:sdDataset patents
28 rdf:type sgo:Patent
29 N1330dcdb9ae14d8a9b33d7bd19d1c074 schema:name Malcolm L. Gefter
30 rdf:type schema:Person
31 N4a17cbc76d884fa4ac56f71f44f4ea43 schema:name Mark Ptashne
32 rdf:type schema:Person
33 N4e991cdf4dd24e4885456a86cefd472b rdf:first Na4a81ad7a6724694a967eab2555457ae
34 rdf:rest rdf:nil
35 N5b5c3135f61a4b0cba0360ecea1cfd5d rdf:first N4a17cbc76d884fa4ac56f71f44f4ea43
36 rdf:rest N4e991cdf4dd24e4885456a86cefd472b
37 Na4a81ad7a6724694a967eab2555457ae schema:name Jacqueline Sharon
38 rdf:type schema:Person
39 Naa6d429eede8401b9de01cc3c9bf5ca0 schema:name Springer Nature - SN SciGraph project
40 rdf:type schema:Organization
41 Nf006e63c4cf4497dbd1e8b56c84a1668 rdf:first N1330dcdb9ae14d8a9b33d7bd19d1c074
42 rdf:rest N5b5c3135f61a4b0cba0360ecea1cfd5d
43 anzsrc-for:3103 schema:inDefinedTermSet anzsrc-for:
44 rdf:type schema:DefinedTerm
45 sg:pub.10.1038/309364a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019506442
46 https://doi.org/10.1038/309364a0
47 rdf:type schema:CreativeWork
48 sg:pub.10.1038/312643a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017996216
49 https://doi.org/10.1038/312643a0
50 rdf:type schema:CreativeWork
51 https://doi.org/10.1073/pnas.80.3.825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036904999
52 rdf:type schema:CreativeWork
53 https://doi.org/10.1073/pnas.81.21.6851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030102558
54 rdf:type schema:CreativeWork
55 https://www.grid.ac/institutes/grid.116068.8 schema:Organization
 




Preview window. Press ESC to close (or click here)


...