Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers


Ontology type: sgo:Patent     


Patent Info

DATE

1989-08-29T00:00

AUTHORS

Alexander R. Neurath , Stephen B. H. Kent

ABSTRACT

A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Alexander R. Neurath", 
        "type": "Person"
      }, 
      {
        "name": "Stephen B. H. Kent", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf02327089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023829055", 
          "https://doi.org/10.1007/bf02327089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02327089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023829055", 
          "https://doi.org/10.1007/bf02327089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/289373a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032880486", 
          "https://doi.org/10.1038/289373a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198502213120806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034031480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.79.24.7871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034374371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08820138309066866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035831916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.80.16.4949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039287430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000149327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040985468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0042-6822(83)90119-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041141688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/295158a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042872425", 
          "https://doi.org/10.1038/295158a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.78.6.3824", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047301083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/317145a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048446499", 
          "https://doi.org/10.1038/317145a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/318663a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052023912", 
          "https://doi.org/10.1038/318663a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.6200931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062635706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1982.tb01262.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081617042"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1989-08-29T00:00", 
    "description": "

A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.

", "id": "sg:patent.US-4861588-A", "keywords": [ "immunogen", "vaccine", "diagnostics", "lipid vesicle", "hepatitis", "peptide", "amino acid", "gene", "envelope", "hepatitis B virus", "amino acid sequence", "envelope protein", "diluent", "carrier", "cross-linking", "out surface", "novel peptide", "surface antigen", "synthetic peptide analog", "viral protein", "allergen", "protein", "human", "animal", "invention", "antigen", "antibody" ], "name": "Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.20861.3d", "type": "Organization" }, { "id": "https://www.grid.ac/institutes/grid.250415.7", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-4861588-A" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:26", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_02955.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-4861588-A'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-4861588-A'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-4861588-A'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-4861588-A'


 

This table displays all metadata directly associated to this object as RDF triples.

102 TRIPLES      15 PREDICATES      56 URIs      35 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-4861588-A schema:about anzsrc-for:3114
2 schema:author Na45450edec9c40789846183e89ecadc2
3 schema:citation sg:pub.10.1007/bf02327089
4 sg:pub.10.1038/289373a0
5 sg:pub.10.1038/295158a0
6 sg:pub.10.1038/317145a0
7 sg:pub.10.1038/318663a0
8 https://doi.org/10.1002/j.1460-2075.1982.tb01262.x
9 https://doi.org/10.1016/0042-6822(83)90119-8
10 https://doi.org/10.1056/nejm198502213120806
11 https://doi.org/10.1073/pnas.78.6.3824
12 https://doi.org/10.1073/pnas.79.24.7871
13 https://doi.org/10.1073/pnas.80.16.4949
14 https://doi.org/10.1126/science.6200931
15 https://doi.org/10.1159/000149327
16 https://doi.org/10.3109/08820138309066866
17 schema:datePublished 1989-08-29T00:00
18 schema:description <p>A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.</p>
19 schema:keywords allergen
20 amino acid
21 amino acid sequence
22 animal
23 antibody
24 antigen
25 carrier
26 cross-linking
27 diagnostics
28 diluent
29 envelope
30 envelope protein
31 gene
32 hepatitis
33 hepatitis B virus
34 human
35 immunogen
36 invention
37 lipid vesicle
38 novel peptide
39 out surface
40 peptide
41 protein
42 surface antigen
43 synthetic peptide analog
44 vaccine
45 viral protein
46 schema:name Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers
47 schema:recipient https://www.grid.ac/institutes/grid.20861.3d
48 https://www.grid.ac/institutes/grid.250415.7
49 schema:sameAs https://app.dimensions.ai/details/patent/US-4861588-A
50 schema:sdDatePublished 2019-04-18T10:26
51 schema:sdLicense https://scigraph.springernature.com/explorer/license/
52 schema:sdPublisher Nc7265e521e0c471786d109a386341d55
53 sgo:license sg:explorer/license/
54 sgo:sdDataset patents
55 rdf:type sgo:Patent
56 N019add4f1d2149cc9e7f33d7fc578b6b schema:name Alexander R. Neurath
57 rdf:type schema:Person
58 Na45450edec9c40789846183e89ecadc2 rdf:first N019add4f1d2149cc9e7f33d7fc578b6b
59 rdf:rest Nce773af27ac04b9396f52c6c82ad9d05
60 Nc7265e521e0c471786d109a386341d55 schema:name Springer Nature - SN SciGraph project
61 rdf:type schema:Organization
62 Nce773af27ac04b9396f52c6c82ad9d05 rdf:first Nf610d5ce089544658d2dd9036d7e7baf
63 rdf:rest rdf:nil
64 Nf610d5ce089544658d2dd9036d7e7baf schema:name Stephen B. H. Kent
65 rdf:type schema:Person
66 anzsrc-for:3114 schema:inDefinedTermSet anzsrc-for:
67 rdf:type schema:DefinedTerm
68 sg:pub.10.1007/bf02327089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023829055
69 https://doi.org/10.1007/bf02327089
70 rdf:type schema:CreativeWork
71 sg:pub.10.1038/289373a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032880486
72 https://doi.org/10.1038/289373a0
73 rdf:type schema:CreativeWork
74 sg:pub.10.1038/295158a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042872425
75 https://doi.org/10.1038/295158a0
76 rdf:type schema:CreativeWork
77 sg:pub.10.1038/317145a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048446499
78 https://doi.org/10.1038/317145a0
79 rdf:type schema:CreativeWork
80 sg:pub.10.1038/318663a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052023912
81 https://doi.org/10.1038/318663a0
82 rdf:type schema:CreativeWork
83 https://doi.org/10.1002/j.1460-2075.1982.tb01262.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1081617042
84 rdf:type schema:CreativeWork
85 https://doi.org/10.1016/0042-6822(83)90119-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041141688
86 rdf:type schema:CreativeWork
87 https://doi.org/10.1056/nejm198502213120806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034031480
88 rdf:type schema:CreativeWork
89 https://doi.org/10.1073/pnas.78.6.3824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047301083
90 rdf:type schema:CreativeWork
91 https://doi.org/10.1073/pnas.79.24.7871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034374371
92 rdf:type schema:CreativeWork
93 https://doi.org/10.1073/pnas.80.16.4949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039287430
94 rdf:type schema:CreativeWork
95 https://doi.org/10.1126/science.6200931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062635706
96 rdf:type schema:CreativeWork
97 https://doi.org/10.1159/000149327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040985468
98 rdf:type schema:CreativeWork
99 https://doi.org/10.3109/08820138309066866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035831916
100 rdf:type schema:CreativeWork
101 https://www.grid.ac/institutes/grid.20861.3d schema:Organization
102 https://www.grid.ac/institutes/grid.250415.7 schema:Organization
 




Preview window. Press ESC to close (or click here)


...