Tm-Enhanced Blocking Oligonucleotides And Baits For Improved Target Enrichment And Reduced Off-Target Selection


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Mark Aaron Behlke , John Robert Havens , Mirna Jarosz , Zachary Zwirko , Doron Lipson , Frank Soo Juhn

ABSTRACT

The invention is directed to modified oligonucleotide compositions and methods for selectively reducing unwanted nucleic acid contaminants and enriching for desired nucleic acid targets from complex genomic nucleic acid mixtures for sequencing applications. The modified oligonucleotide compositions include one or more modified groups that increase the Tm of the resultant oligonucleotide composition. More... »

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