Secretion Of Recombinant Polypeptides In The Extracellular Medium Of Diatoms


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Alexandre Lejeune , Rémy Michel , Jean-Paul Cadoret , Aude Carlier

ABSTRACT

A transformed diatom includes a nucleic acid sequence operatively linked to a promoter, wherein the nucleic acid sequence encodes an amino acid sequence including (i) an heterologous signal peptide and (ii) a polypeptide, the heterologous signal peptide leading to the secretion of the polypeptide in the extracellular medium of the transformed diatom; a method for producing a polypeptide which is secreted in the extracellular medium, the method including the steps of (i) culturing a transformed diatom, (ii) harvesting the extracellular medium of the culture and (iii) purifying the secreted polypeptide in the extracellular medium; and use of the transformed diatom for the secretion of a polypeptide in the extracellular medium. More... »

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