Use Of Cxcr4 Protein Expression On The Surface Of Stem Cells As A Marker For Tumor Tropic Potential


Ontology type: sgo:Patent     


Patent Info

DATE

2011-10-20T00:00

AUTHORS

John S. Yu , Moneeb Ehtesham

ABSTRACT

The present invention relates to tumor tropic stem cells, and particularly to neural stem cells, and their use as delivery vehicles for therapeutic gene products to neoplastic foci. The stem cells with tumor tropic potential are selected based on the stem cells exhibiting CXCR4 receptors or an affinity for the chemokine SDF-1. The stem cells may additionally exhibit markers characteristic of astrocytic progenitors. The stem cells may be administered as part of a treatment regimen including the chemokine SDF-1. More... »

Related SciGraph Publications

  • 2003-09. Cancer: Cues for migration in NATURE
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2995", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "John S. Yu", 
            "type": "Person"
          }, 
          {
            "name": "Moneeb Ehtesham", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/425247a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023371493", 
              "https://doi.org/10.1038/425247a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/425247a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023371493", 
              "https://doi.org/10.1038/425247a"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-10-20T00:00", 
        "description": "

    The present invention relates to tumor tropic stem cells, and particularly to neural stem cells, and their use as delivery vehicles for therapeutic gene products to neoplastic foci. The stem cells with tumor tropic potential are selected based on the stem cells exhibiting CXCR4 receptors or an affinity for the chemokine SDF-1. The stem cells may additionally exhibit markers characteristic of astrocytic progenitors. The stem cells may be administered as part of a treatment regimen including the chemokine SDF-1.

    ", "id": "sg:patent.US-20110256555-A1", "keywords": [ "protein expression", "stem cell", "marker", "invention", "neural stem cell", "delivery vehicle", "therapeutic gene product", "Neoplasm", "CXCR4 receptor", "affinity", "chemokines", "progenitor", "treatment regimen" ], "name": "USE OF CXCR4 PROTEIN EXPRESSION ON THE SURFACE OF STEM CELLS AS A MARKER FOR TUMOR TROPIC POTENTIAL", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.50956.3f", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-20110256555-A1" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:08", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_00263.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-20110256555-A1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-20110256555-A1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-20110256555-A1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-20110256555-A1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    43 TRIPLES      15 PREDICATES      28 URIs      21 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-20110256555-A1 schema:about anzsrc-for:2995
    2 schema:author Nd5f11da6d15a4381b14b8e073126f079
    3 schema:citation sg:pub.10.1038/425247a
    4 schema:datePublished 2011-10-20T00:00
    5 schema:description <p id="p-0001" num="0000">The present invention relates to tumor tropic stem cells, and particularly to neural stem cells, and their use as delivery vehicles for therapeutic gene products to neoplastic foci. The stem cells with tumor tropic potential are selected based on the stem cells exhibiting CXCR4 receptors or an affinity for the chemokine SDF-1. The stem cells may additionally exhibit markers characteristic of astrocytic progenitors. The stem cells may be administered as part of a treatment regimen including the chemokine SDF-1.</p>
    6 schema:keywords CXCR4 receptor
    7 Neoplasm
    8 affinity
    9 chemokines
    10 delivery vehicle
    11 invention
    12 marker
    13 neural stem cell
    14 progenitor
    15 protein expression
    16 stem cell
    17 therapeutic gene product
    18 treatment regimen
    19 schema:name USE OF CXCR4 PROTEIN EXPRESSION ON THE SURFACE OF STEM CELLS AS A MARKER FOR TUMOR TROPIC POTENTIAL
    20 schema:recipient https://www.grid.ac/institutes/grid.50956.3f
    21 schema:sameAs https://app.dimensions.ai/details/patent/US-20110256555-A1
    22 schema:sdDatePublished 2019-04-18T10:08
    23 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    24 schema:sdPublisher N3f02f2f1b4eb40168c273dfa98358086
    25 sgo:license sg:explorer/license/
    26 sgo:sdDataset patents
    27 rdf:type sgo:Patent
    28 N23d7668dc67d4fa2b0660f2fbb2af2f7 rdf:first N38dd9a1deb7e4c30a99cf092e720834e
    29 rdf:rest rdf:nil
    30 N38dd9a1deb7e4c30a99cf092e720834e schema:name Moneeb Ehtesham
    31 rdf:type schema:Person
    32 N3f02f2f1b4eb40168c273dfa98358086 schema:name Springer Nature - SN SciGraph project
    33 rdf:type schema:Organization
    34 Na36ead29237e4655946ab5bb51dc60c2 schema:name John S. Yu
    35 rdf:type schema:Person
    36 Nd5f11da6d15a4381b14b8e073126f079 rdf:first Na36ead29237e4655946ab5bb51dc60c2
    37 rdf:rest N23d7668dc67d4fa2b0660f2fbb2af2f7
    38 anzsrc-for:2995 schema:inDefinedTermSet anzsrc-for:
    39 rdf:type schema:DefinedTerm
    40 sg:pub.10.1038/425247a schema:sameAs https://app.dimensions.ai/details/publication/pub.1023371493
    41 https://doi.org/10.1038/425247a
    42 rdf:type schema:CreativeWork
    43 https://www.grid.ac/institutes/grid.50956.3f schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...