Compounds that inhibit Mcl-1 protein


Ontology type: sgo:Patent     


Patent Info

DATE

2022-06-21T00:00

AUTHORS

BROWN SEAN P , LI KEXUE , LI YUNXIAO , REED ANTHONY B , LANMAN BRIAN ALAN

ABSTRACT

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer. More... »

Related SciGraph Publications

  • 2008-12-16. Mcl-1 is a potential therapeutic target in multiple types of cancer in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2008-12. BCL-2 family antagonists for cancer therapy in NATURE REVIEWS DRUG DISCOVERY
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0305", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "BROWN SEAN P", 
            "type": "Person"
          }, 
          {
            "name": "LI KEXUE", 
            "type": "Person"
          }, 
          {
            "name": "LI YUNXIAO", 
            "type": "Person"
          }, 
          {
            "name": "REED ANTHONY B", 
            "type": "Person"
          }, 
          {
            "name": "LANMAN BRIAN ALAN", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00018-008-8637-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023498818", 
              "https://doi.org/10.1007/s00018-008-8637-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030857223", 
              "https://doi.org/10.1038/nrd2658"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2022-06-21T00:00", 
        "description": "

    Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I,

    \n

    \"embedded
    \nor a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.\n

    ", "endDate": "2039-04-04", "id": "sg:patent.US-11364248-B2", "name": "Compounds that inhibit Mcl-1 protein", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.417886.4", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-11364248-B2" ], "sdDataset": "patents", "sdDatePublished": "2022-09-02T16:21", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/patent/patent_8.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-11364248-B2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-11364248-B2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-11364248-B2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-11364248-B2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    50 TRIPLES      15 PREDICATES      18 URIs      9 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-11364248-B2 schema:about anzsrc-for:03
    2 anzsrc-for:0305
    3 schema:author N66334907a7b245fca2e010ba8cfb1f7a
    4 schema:citation sg:pub.10.1007/s00018-008-8637-6
    5 sg:pub.10.1038/nrd2658
    6 schema:datePublished 2022-06-21T00:00
    7 schema:description <p id="p-0001" num="0000">Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I,</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"><img id="EMI-C00001" he="39.62mm" wi="71.80mm" file="US11364248-20220621-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif" orientation="portrait" inline="no"/><attachments><attachment idref="CHEM-US-00001" attachment-type="cdx" file="US11364248-20220621-C00001.CDX"/><attachment idref="CHEM-US-00001" attachment-type="mol" file="US11364248-20220621-C00001.MOL"/></attachments></chemistry><br/> or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer. </p>
    8 schema:endDate 2039-04-04
    9 schema:name Compounds that inhibit Mcl-1 protein
    10 schema:recipient grid-institutes:grid.417886.4
    11 schema:sameAs https://app.dimensions.ai/details/patent/US-11364248-B2
    12 schema:sdDatePublished 2022-09-02T16:21
    13 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    14 schema:sdPublisher Nc2c693f953b0496281b50d94ea9530cf
    15 sgo:license sg:explorer/license/
    16 sgo:sdDataset patents
    17 rdf:type sgo:Patent
    18 N0aa0166d36884ad7b1ad143193ea39ec rdf:first Ne15f85d6e3c6414d94b9991749d3576b
    19 rdf:rest Nb9ce3874d59747f4a29322b5a65b9a63
    20 N1f4b304d89c24ec893bb797f9927a0d9 schema:name LI YUNXIAO
    21 rdf:type schema:Person
    22 N267a177e98804c18a0224f2075e2b516 schema:name LANMAN BRIAN ALAN
    23 rdf:type schema:Person
    24 N27b1ade0c43b4779a55e5f7ef34642ff schema:name BROWN SEAN P
    25 rdf:type schema:Person
    26 N66334907a7b245fca2e010ba8cfb1f7a rdf:first N27b1ade0c43b4779a55e5f7ef34642ff
    27 rdf:rest N0aa0166d36884ad7b1ad143193ea39ec
    28 N6d2fcc6016f74ae29bdfe8e64fcf75cb rdf:first N267a177e98804c18a0224f2075e2b516
    29 rdf:rest rdf:nil
    30 Nb9ce3874d59747f4a29322b5a65b9a63 rdf:first N1f4b304d89c24ec893bb797f9927a0d9
    31 rdf:rest Nbac1b77b0cbc470bac28c42456d9d73c
    32 Nbac1b77b0cbc470bac28c42456d9d73c rdf:first Ne09aa76d9ad44c599b66dcfc22089d0a
    33 rdf:rest N6d2fcc6016f74ae29bdfe8e64fcf75cb
    34 Nc2c693f953b0496281b50d94ea9530cf schema:name Springer Nature - SN SciGraph project
    35 rdf:type schema:Organization
    36 Ne09aa76d9ad44c599b66dcfc22089d0a schema:name REED ANTHONY B
    37 rdf:type schema:Person
    38 Ne15f85d6e3c6414d94b9991749d3576b schema:name LI KEXUE
    39 rdf:type schema:Person
    40 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
    41 rdf:type schema:DefinedTerm
    42 anzsrc-for:0305 schema:inDefinedTermSet anzsrc-for:
    43 rdf:type schema:DefinedTerm
    44 sg:pub.10.1007/s00018-008-8637-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023498818
    45 https://doi.org/10.1007/s00018-008-8637-6
    46 rdf:type schema:CreativeWork
    47 sg:pub.10.1038/nrd2658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030857223
    48 https://doi.org/10.1038/nrd2658
    49 rdf:type schema:CreativeWork
    50 grid-institutes:grid.417886.4 schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...