Compounds that inhibit MCL-1 protein


Ontology type: sgo:Patent     


Patent Info

DATE

2022-04-19T00:00

AUTHORS

BROWN SEAN P , BEDKE DAVID KARL , DEGRAFFENREID MICHAEL R , FU JIASHENG , LI ZHIHONG , GONZALEZ LOPEZ DE TURISO FELIX , GONZALEZ BUENROSTRO ANA , GRIBBLE JR MICHAEL W , JOHNSON MICHAEL G , KOHN TODD J , LI KEXUE , LI YUNXIAO , LIZARZABURU MIKE ELIAS , REW YOSUP , TAYGERLY JOSHUA , WANG YINGCAI , YAN XUELEI , YU MING , ZHU JIANG , ZANCANELLA MANUEL , JIAO XIAN YUN , ZHU LIUSHENG , WANG XIANGHONG , MEDINA JULIO C , DUQUETTE JASON A , HOUZE JONATHAN B , VIMOLRATANA MARC , CARDOZO MARIO G , CHENG ALAN C

ABSTRACT

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer. More... »

Related SciGraph Publications

  • 2008-12-16. Mcl-1 is a potential therapeutic target in multiple types of cancer in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2008-12. BCL-2 family antagonists for cancer therapy in NATURE REVIEWS DRUG DISCOVERY
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