Compounds that inhibit MCL-1 protein


Ontology type: sgo:Patent     


Patent Info

DATE

2022-04-19T00:00

AUTHORS

BROWN SEAN P , BEDKE DAVID KARL , DEGRAFFENREID MICHAEL R , FU JIASHENG , LI ZHIHONG , GONZALEZ LOPEZ DE TURISO FELIX , GONZALEZ BUENROSTRO ANA , GRIBBLE JR MICHAEL W , JOHNSON MICHAEL G , KOHN TODD J , LI KEXUE , LI YUNXIAO , LIZARZABURU MIKE ELIAS , REW YOSUP , TAYGERLY JOSHUA , WANG YINGCAI , YAN XUELEI , YU MING , ZHU JIANG , ZANCANELLA MANUEL , JIAO XIAN YUN , ZHU LIUSHENG , WANG XIANGHONG , MEDINA JULIO C , DUQUETTE JASON A , HOUZE JONATHAN B , VIMOLRATANA MARC , CARDOZO MARIO G , CHENG ALAN C

ABSTRACT

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer. More... »

Related SciGraph Publications

  • 2008-12-16. Mcl-1 is a potential therapeutic target in multiple types of cancer in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2008-12. BCL-2 family antagonists for cancer therapy in NATURE REVIEWS DRUG DISCOVERY
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/32", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3211", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "BROWN SEAN P", 
            "type": "Person"
          }, 
          {
            "name": "BEDKE DAVID KARL", 
            "type": "Person"
          }, 
          {
            "name": "DEGRAFFENREID MICHAEL R", 
            "type": "Person"
          }, 
          {
            "name": "FU JIASHENG", 
            "type": "Person"
          }, 
          {
            "name": "LI ZHIHONG", 
            "type": "Person"
          }, 
          {
            "name": "GONZALEZ LOPEZ DE TURISO FELIX", 
            "type": "Person"
          }, 
          {
            "name": "GONZALEZ BUENROSTRO ANA", 
            "type": "Person"
          }, 
          {
            "name": "GRIBBLE JR MICHAEL W", 
            "type": "Person"
          }, 
          {
            "name": "JOHNSON MICHAEL G", 
            "type": "Person"
          }, 
          {
            "name": "KOHN TODD J", 
            "type": "Person"
          }, 
          {
            "name": "LI KEXUE", 
            "type": "Person"
          }, 
          {
            "name": "LI YUNXIAO", 
            "type": "Person"
          }, 
          {
            "name": "LIZARZABURU MIKE ELIAS", 
            "type": "Person"
          }, 
          {
            "name": "REW YOSUP", 
            "type": "Person"
          }, 
          {
            "name": "TAYGERLY JOSHUA", 
            "type": "Person"
          }, 
          {
            "name": "WANG YINGCAI", 
            "type": "Person"
          }, 
          {
            "name": "YAN XUELEI", 
            "type": "Person"
          }, 
          {
            "name": "YU MING", 
            "type": "Person"
          }, 
          {
            "name": "ZHU JIANG", 
            "type": "Person"
          }, 
          {
            "name": "ZANCANELLA MANUEL", 
            "type": "Person"
          }, 
          {
            "name": "JIAO XIAN YUN", 
            "type": "Person"
          }, 
          {
            "name": "ZHU LIUSHENG", 
            "type": "Person"
          }, 
          {
            "name": "WANG XIANGHONG", 
            "type": "Person"
          }, 
          {
            "name": "MEDINA JULIO C", 
            "type": "Person"
          }, 
          {
            "name": "DUQUETTE JASON A", 
            "type": "Person"
          }, 
          {
            "name": "HOUZE JONATHAN B", 
            "type": "Person"
          }, 
          {
            "name": "VIMOLRATANA MARC", 
            "type": "Person"
          }, 
          {
            "name": "CARDOZO MARIO G", 
            "type": "Person"
          }, 
          {
            "name": "CHENG ALAN C", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00018-008-8637-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023498818", 
              "https://doi.org/10.1007/s00018-008-8637-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030857223", 
              "https://doi.org/10.1038/nrd2658"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2022-04-19T00:00", 
        "description": "

    Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I,

    \n

    \"embedded
    \nand pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.\n

    ", "endDate": "2039-04-18", "id": "sg:patent.US-11306107-B2", "name": "Compounds that inhibit MCL-1 protein", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.417886.4", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-11306107-B2" ], "sdDataset": "patents", "sdDatePublished": "2022-11-24T21:23", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/patent/patent_4.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-11306107-B2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-11306107-B2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-11306107-B2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-11306107-B2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    146 TRIPLES      15 PREDICATES      18 URIs      9 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-11306107-B2 schema:about anzsrc-for:32
    2 anzsrc-for:3211
    3 schema:author N329f9a2ee9ee491699d410a171f8524b
    4 schema:citation sg:pub.10.1007/s00018-008-8637-6
    5 sg:pub.10.1038/nrd2658
    6 schema:datePublished 2022-04-19T00:00
    7 schema:description <p id="p-0001" num="0000">Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I,</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"><img id="EMI-C00001" he="43.18mm" wi="73.15mm" file="US11306107-20220419-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif" orientation="portrait" inline="no"/><attachments><attachment idref="CHEM-US-00001" attachment-type="cdx" file="US11306107-20220419-C00001.CDX"/><attachment idref="CHEM-US-00001" attachment-type="mol" file="US11306107-20220419-C00001.MOL"/></attachments></chemistry><br/> and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer. </p>
    8 schema:endDate 2039-04-18
    9 schema:name Compounds that inhibit MCL-1 protein
    10 schema:recipient grid-institutes:grid.417886.4
    11 schema:sameAs https://app.dimensions.ai/details/patent/US-11306107-B2
    12 schema:sdDatePublished 2022-11-24T21:23
    13 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    14 schema:sdPublisher Nc0a79633c2a5437fb5c3dba681a39d6d
    15 sgo:license sg:explorer/license/
    16 sgo:sdDataset patents
    17 rdf:type sgo:Patent
    18 N029752cc9a464b628fb4d43ecce739a8 rdf:first N0de817311f4c4461b03da0956cf977ca
    19 rdf:rest N41fa0db7178f4ee68b56e9aa35344442
    20 N0571964922af465a8ddf33da4f23c856 schema:name JOHNSON MICHAEL G
    21 rdf:type schema:Person
    22 N06dd11fb78b642c6ac2344e5bc6e1016 schema:name YU MING
    23 rdf:type schema:Person
    24 N0de817311f4c4461b03da0956cf977ca schema:name JIAO XIAN YUN
    25 rdf:type schema:Person
    26 N1bf9dd7ab3d2422590b9150117532e51 rdf:first N3939208669ed4ff1a3c6a7fb052c1210
    27 rdf:rest N2c0c576730604e8bb2d77221ad0ea0b8
    28 N2005e5199f0f421089e04df756f62c5c schema:name BEDKE DAVID KARL
    29 rdf:type schema:Person
    30 N2317c16b17b64455ac03c6f0246dea39 rdf:first Nc533f7cdb271469a903eceb97ff27b70
    31 rdf:rest N5679b9e04e364d918475d20d7cf4bdd0
    32 N24bb486868a54641b1245c9bdf25cbd9 rdf:first N2005e5199f0f421089e04df756f62c5c
    33 rdf:rest Nfdc3263d116c4c08a87e9a3c16640bb3
    34 N287ec948ade1439cbbb9e449ee00ef63 schema:name LI KEXUE
    35 rdf:type schema:Person
    36 N2c0c576730604e8bb2d77221ad0ea0b8 rdf:first N80098025e1414ad4965778ab6b833cdc
    37 rdf:rest N6ae2a93052bd441681d9f5e5c0b082de
    38 N2c7e484c306d416e9f8a9f37788ab5ac schema:name FU JIASHENG
    39 rdf:type schema:Person
    40 N329f9a2ee9ee491699d410a171f8524b rdf:first Nf6fb3fa5f51c4ff1964b42f6ea53c054
    41 rdf:rest N24bb486868a54641b1245c9bdf25cbd9
    42 N3607861ba50b472fb0557f78a68a6a8a rdf:first N06dd11fb78b642c6ac2344e5bc6e1016
    43 rdf:rest N755494e9c94e42d1b84cbcff6909d1d6
    44 N3939208669ed4ff1a3c6a7fb052c1210 schema:name GONZALEZ LOPEZ DE TURISO FELIX
    45 rdf:type schema:Person
    46 N3c82b01bb03941e092c6f53bf382f8b1 rdf:first N287ec948ade1439cbbb9e449ee00ef63
    47 rdf:rest N84fa324187264f82b614ee47619988c6
    48 N41d847496c21455587d991eee2bdf78f rdf:first N6003aada794b465982297b65e2a58b15
    49 rdf:rest Nc1e2f481141b4b0bbd14c919a077b123
    50 N41fa0db7178f4ee68b56e9aa35344442 rdf:first Neff809aaccca4225809d6652cc4c829b
    51 rdf:rest Nb77a6aa0769947668fb05e9f2c603ae9
    52 N4e3e82b92a834851ade9d56ef973cb8d rdf:first Nd4a147bb30a34903b4ac6ec210b87043
    53 rdf:rest N69bb4aa44d854f24baf3508af63ce58a
    54 N50601c12cc374d029796a8229ca19b54 schema:name MEDINA JULIO C
    55 rdf:type schema:Person
    56 N5679b9e04e364d918475d20d7cf4bdd0 rdf:first Nf4cd3f5043c64e22a1e7afc37bebf38e
    57 rdf:rest Nf156b1671bda40b0bdd35a056dd74f6c
    58 N5de05c642fb648a49a012d3539d5885f schema:name LIZARZABURU MIKE ELIAS
    59 rdf:type schema:Person
    60 N6003aada794b465982297b65e2a58b15 schema:name HOUZE JONATHAN B
    61 rdf:type schema:Person
    62 N69bb4aa44d854f24baf3508af63ce58a rdf:first Naeeef7d6f8ac48999d42adec9b5d4f13
    63 rdf:rest rdf:nil
    64 N6ae2a93052bd441681d9f5e5c0b082de rdf:first Ned37a1d361024fae9ee7f055a00f369c
    65 rdf:rest Nd95a9f0e573a4afead6e2742e64f0278
    66 N755494e9c94e42d1b84cbcff6909d1d6 rdf:first Nf31f1cc174454464a87cf0fd8d886bd4
    67 rdf:rest Nea1706c909ae4f3d9e2add0b5f814e29
    68 N7738e13b956e4d5292fe9c6f5ed14d67 rdf:first N2c7e484c306d416e9f8a9f37788ab5ac
    69 rdf:rest Nb91b8fef9d044e019f3039ca6236c781
    70 N78c78c597134491b9bdf17e7ee91136c schema:name LI YUNXIAO
    71 rdf:type schema:Person
    72 N7dad4aa94d194afb96f692e8d692dc7f rdf:first Na568213fb63f4a86ab9cd54e2c1d316d
    73 rdf:rest N2317c16b17b64455ac03c6f0246dea39
    74 N80098025e1414ad4965778ab6b833cdc schema:name GONZALEZ BUENROSTRO ANA
    75 rdf:type schema:Person
    76 N84fa324187264f82b614ee47619988c6 rdf:first N78c78c597134491b9bdf17e7ee91136c
    77 rdf:rest Nd9daea5489ad45789ae140dcd4d122d3
    78 N86b6fa736e5a4f6898cfde37974cc4e4 rdf:first Nf2fa6b2333ff4782bbec0126fae2a5d7
    79 rdf:rest N3c82b01bb03941e092c6f53bf382f8b1
    80 N886c360f35de4c838821949b4f13c38b schema:name WANG XIANGHONG
    81 rdf:type schema:Person
    82 N89192536a88f47bd9861d2a9152e7c96 schema:name VIMOLRATANA MARC
    83 rdf:type schema:Person
    84 N9083035a1fb14e798fedf09fb07ba9a1 rdf:first Nb5f5428c0c6043bc8c03d9df562ca9f2
    85 rdf:rest N41d847496c21455587d991eee2bdf78f
    86 N94597156923d498a94e24525bc083668 schema:name DEGRAFFENREID MICHAEL R
    87 rdf:type schema:Person
    88 Na568213fb63f4a86ab9cd54e2c1d316d schema:name REW YOSUP
    89 rdf:type schema:Person
    90 Naeeef7d6f8ac48999d42adec9b5d4f13 schema:name CHENG ALAN C
    91 rdf:type schema:Person
    92 Nb1805a246df64d52b24ff7d1ec8d543a schema:name ZANCANELLA MANUEL
    93 rdf:type schema:Person
    94 Nb5f5428c0c6043bc8c03d9df562ca9f2 schema:name DUQUETTE JASON A
    95 rdf:type schema:Person
    96 Nb77a6aa0769947668fb05e9f2c603ae9 rdf:first N886c360f35de4c838821949b4f13c38b
    97 rdf:rest Nf1e3e8265ce3481ba8f0c9e8ec36515a
    98 Nb91b8fef9d044e019f3039ca6236c781 rdf:first Nd5191b5fa7c74302a9607fe28f36a1b2
    99 rdf:rest N1bf9dd7ab3d2422590b9150117532e51
    100 Nc0a79633c2a5437fb5c3dba681a39d6d schema:name Springer Nature - SN SciGraph project
    101 rdf:type schema:Organization
    102 Nc1e2f481141b4b0bbd14c919a077b123 rdf:first N89192536a88f47bd9861d2a9152e7c96
    103 rdf:rest N4e3e82b92a834851ade9d56ef973cb8d
    104 Nc533f7cdb271469a903eceb97ff27b70 schema:name TAYGERLY JOSHUA
    105 rdf:type schema:Person
    106 Nd4a147bb30a34903b4ac6ec210b87043 schema:name CARDOZO MARIO G
    107 rdf:type schema:Person
    108 Nd5191b5fa7c74302a9607fe28f36a1b2 schema:name LI ZHIHONG
    109 rdf:type schema:Person
    110 Nd95a9f0e573a4afead6e2742e64f0278 rdf:first N0571964922af465a8ddf33da4f23c856
    111 rdf:rest N86b6fa736e5a4f6898cfde37974cc4e4
    112 Nd9daea5489ad45789ae140dcd4d122d3 rdf:first N5de05c642fb648a49a012d3539d5885f
    113 rdf:rest N7dad4aa94d194afb96f692e8d692dc7f
    114 Ndaef6a2940064c2289c1f4bc2250d5d3 schema:name YAN XUELEI
    115 rdf:type schema:Person
    116 Nea1706c909ae4f3d9e2add0b5f814e29 rdf:first Nb1805a246df64d52b24ff7d1ec8d543a
    117 rdf:rest N029752cc9a464b628fb4d43ecce739a8
    118 Ned37a1d361024fae9ee7f055a00f369c schema:name GRIBBLE JR MICHAEL W
    119 rdf:type schema:Person
    120 Neff809aaccca4225809d6652cc4c829b schema:name ZHU LIUSHENG
    121 rdf:type schema:Person
    122 Nf156b1671bda40b0bdd35a056dd74f6c rdf:first Ndaef6a2940064c2289c1f4bc2250d5d3
    123 rdf:rest N3607861ba50b472fb0557f78a68a6a8a
    124 Nf1e3e8265ce3481ba8f0c9e8ec36515a rdf:first N50601c12cc374d029796a8229ca19b54
    125 rdf:rest N9083035a1fb14e798fedf09fb07ba9a1
    126 Nf2fa6b2333ff4782bbec0126fae2a5d7 schema:name KOHN TODD J
    127 rdf:type schema:Person
    128 Nf31f1cc174454464a87cf0fd8d886bd4 schema:name ZHU JIANG
    129 rdf:type schema:Person
    130 Nf4cd3f5043c64e22a1e7afc37bebf38e schema:name WANG YINGCAI
    131 rdf:type schema:Person
    132 Nf6fb3fa5f51c4ff1964b42f6ea53c054 schema:name BROWN SEAN P
    133 rdf:type schema:Person
    134 Nfdc3263d116c4c08a87e9a3c16640bb3 rdf:first N94597156923d498a94e24525bc083668
    135 rdf:rest N7738e13b956e4d5292fe9c6f5ed14d67
    136 anzsrc-for:32 schema:inDefinedTermSet anzsrc-for:
    137 rdf:type schema:DefinedTerm
    138 anzsrc-for:3211 schema:inDefinedTermSet anzsrc-for:
    139 rdf:type schema:DefinedTerm
    140 sg:pub.10.1007/s00018-008-8637-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023498818
    141 https://doi.org/10.1007/s00018-008-8637-6
    142 rdf:type schema:CreativeWork
    143 sg:pub.10.1038/nrd2658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030857223
    144 https://doi.org/10.1038/nrd2658
    145 rdf:type schema:CreativeWork
    146 grid-institutes:grid.417886.4 schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...